Robbins, Cotran & Kumar Pathologic Basis of Disease
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**Selected for 2025 Doody’s Core TitlesĀ® with "Essential Purchase" designation in Pathology**Comprehensive, accessible, and highly illustrated, Robbins, Cotran & Kumar Pathologic Basis of Disease, 11th Edition, offers an in-depth, state-of-the-art overview of human diseases and their cellular and molecular basis. This best-selling text delivers the latest, most essential pathology knowledge in a readable, interesting manner, ensuring optimal understanding of the latest basic science and clinical content.
More than 1,000 high-quality photographs and full-color illustrations highlight new information in molecular biology, disease classifications, new drugs and drug therapies, and much more. Ideal for USMLE or specialty board preparation, coursework, or as a clinical reference, this acclaimed text is a must-have resource for students, residents, researchers, academic faculty, and practitioners. Explains concepts in a clear and concise manner, progressing logically from pathogenesis to morphology to clinical features of major human disease entities.
Uses an outstanding full-color, user-friendly design to simplify your study and quickly direct you to the information you need to know, with learning features such as boldface overviews at the beginning of each section, key concepts boxes, selected additional reading, schematic diagrams that illustrate complex concepts, many new and significantly revised figures, and gross and microscopic images depicting disease processes.
Brings you up to date with the latest information on disease pathogenesis, including tumor-host interactions, the pathogenesis and pathology of COVID-19, and the role of the microbiome in non-communicable diseases, as well as current classification systems, molecular and genetic testing, personalized medicine, and targeted therapeutics. Reflects increased attention to diversity and inclusion throughout.
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- Elsevier Limited (UK)
- 9780443283536
- 9780443264528
- ePub
- 11
- Jon C. Aster
- English
- 2025-06-11
- 10
Kaflar
- Robbins, Cotran & Kumar Pathologic Basis of Disease
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- Contributors
- Preface
- Acknowledgments
- List of Illustrations
- List of Tables
- 1. The cell as a unit of health and disease
- The genome
- Cellular housekeeping
- Cellular metabolism and mitochondrial function
- Cellular signaling
- Growth factors and receptors
- Extracellular matrix
- Maintaining cell populations
- Concluding remarks
- Acknowledgment
- Selected readings
- 2. Cell injury, cell death, and adaptations
- Introduction to pathology
- Overview of cellular responses to stress and noxious stimuli
- Pathways of cellular response to stress and injury
- Progression of cell injury and death
- Reversible cell injury
- Cell death
- Mechanisms of cell injury
- Clinicopathologic correlations: Selected examples of cell injury and death
- Adaptations of cellular growth and differentiation
- Intracellular accumulations
- Pathologic calcification
- Cellular aging
- Acknowledgment
- Selected readings
- 3. Inflammation and repair
- Overview of inflammation: Definitions and general features
- Acute inflammation
- Chronic inflammation
- Systemic effects of inflammation
- Tissue repair
- Selected readings
- 4. Hemodynamic disorders, thromboembolic disease, and shock
- Edema and effusions
- Hyperemia and congestion
- Hemostasis, hemorrhagic disorders, and thrombosis
- Embolism
- Infarction
- Shock
- Selected readings
- 5. Genetic disorders
- Genes and human diseases
- Single-gene disorders
- Complex multigenic disorders
- Chromosomal disorders
- Single-gene disorders with nonclassic inheritance
- Molecular genetic diagnosis
- Selected readings
- 6. Diseases of the immune system
- Normal immune response
- Hypersensitivity: Immunologically mediated tissue injury
- Autoimmune diseases
- Rejection of tissue transplants
- Immunodeficiency diseases
- Amyloidosis
- Selected readings
- 7. Neoplasia
- Nomenclature
- Characteristics of benign and malignant neoplasms
- Epidemiology of cancer
- Molecular basis of cancer: Role of genetic and epigenetic alterations
- Cellular and molecular hallmarks of cancer
- Carcinogenic agents and their cellular interactions
- Clinical aspects of neoplasia
- Selected readings
- 8. Infectious diseases
- General principles of microbial pathogenesis
- Viral infections
- Bacterial infections
- Fungal infections
- Parasitic infections
- Agents of bioterrorism
- Selected readings
- 9. Environmental and nutritional diseases
- Health disparities
- Health effects of climate change
- Toxicity of chemical and physical agents
- Environmental pollution
- Occupational health risks: Industrial and agricultural exposures
- Effects of tobacco
- Effects of alcohol
- Injury by therapeutic drugs and drugs of abuse
- Injury by physical agents
- Nutritional diseases
- Selected readings
- 10. Diseases of infancy and childhood
- Congenital anomalies
- Prematurity and fetal growth restriction
- Perinatal infections
- Fetal hydrops
- Inherited metabolic disorders and other genetic disorders
- Sudden infant death syndrome
- Tumors and tumor-like lesions of infancy and childhood
- Selected readings
- 11. Blood vessels
- Vascular structure and function
- Vascular anomalies
- Vascular wall response to injury
- Hypertensive vascular disease
- Arteriosclerosis
- Atherosclerosis
- Aneurysms and dissection
- Vasculitis
- Disorders of blood vessel hyperreactivity
- Veins and lymphatics
- Vascular tumors
- Pathology of vascular intervention
- Selected readings
- 12. The heart
- Cardiac structure and specializations
- Overview of cardiac pathophysiology
- Heart failure
- Congenital heart disease
- Ischemic heart disease
- Arrhythmias
- Hypertensive heart disease
- Valvular heart disease
- Cardiomyopathies
- Pericardial disease
- Tumors of the heart
- Cardiac transplantation
- Cardiac devices
- Selected readings
- 13. Diseases of white blood cells, lymph nodes, spleen, and thymus
- Normal hematopoiesis
- Disorders of white cells
- Leukopenia
- Reactive proliferations of white cells and lymph nodes
- Neoplastic proliferations of white cells: Overview
- Lymphoid neoplasms
- Myeloid neoplasms
- Spleen
- Splenomegaly
- Neoplasms
- Congenital anomalies
- Rupture
- Thymus
- Developmental disorders
- Thymic hyperplasia
- Thymoma
- Selected readings
- 14. Red blood cell and bleeding disorders
- Anemias
- Polycythemia
- Bleeding disorders: Hemorrhagic diatheses
- Selected readings
- 15. The lung
- Congenital anomalies
- Atelectasis (collapse)
- Pulmonary edema
- Acute lung injury and acute respiratory distress syndrome (diffuse alveolar damage)
- Obstructive and restrictive lung diseases
- Obstructive lung diseases
- Chronic diffuse interstitial (restrictive) diseases
- Diseases of vascular origin
- Pulmonary infections
- Lung transplantation
- Tumors
- Pleura
- Selected readings
- 16. Head and neck
- Oral cavity
- Diseases of teeth and supporting structures
- Inflammatory/reactive lesions
- Infections
- Oral manifestations of systemic disease
- Precancerous and cancerous lesions
- Odontogenic cysts and tumors
- Upper airways
- Nose
- Nasopharynx
- Tumors of the nose, sinuses, and nasopharynx
- Larynx
- Ears
- Inflammatory lesions
- Otosclerosis
- Tumors
- Neck
- Branchial cleft cyst (cervical lymphoepithelial cyst)
- Thyroglossal duct cyst
- Paraganglioma
- Salivary glands
- Xerostomia
- Inflammation (sialadenitis)
- Neoplasms
- Selected readings
- 17. The gastrointestinal tract
- Congenital abnormalities
- Atresia, fistulae, and duplications
- Diaphragmatic hernia, omphalocele, and gastroschisis
- Ectopia
- Meckel diverticulum
- Pyloric stenosis
- Hirschsprung disease
- Esophagus
- Esophageal obstruction
- Achalasia
- Esophagitis and related disorders
- Esophageal tumors
- Stomach
- Gastropathy and acute gastritis
- Stress-related mucosal disease
- Chronic gastritis and its complications
- Hypertrophic gastropathies
- Gastric polyps and tumors
- Small intestine and colon
- Intestinal obstruction
- Ischemic bowel disease
- Angiodysplasia
- Malabsorption and diarrhea
- Infectious enterocolitis
- Irritable bowel syndrome
- Inflammatory bowel disease
- Sigmoid diverticular disease
- Intestinal polyps
- Premalignant and malignant lesions
- Anal canal
- Appendix
- Peritoneal cavity
- Peritonitis
- Tumors
- Selected readings
- 18. Liver and gallbladder
- Liver and bile ducts
- General features of liver disease
- Infectious disorders
- Autoimmune hepatitis
- Drug- and toxin-induced liver injury
- Steatotic liver disease
- Inherited liver disease
- Cholestatic disease
- Structural anomalies of the biliary tree
- Circulatory disorders
- Hepatic disease associated with pregnancy
- Nodules and tumors
- Gallbladder
- Congenital anomalies
- Cholelithiasis (gallstones)
- Cholecystitis
- Gallbladder carcinoma
- Selected readings
- 19. The pancreas
- Congenital anomalies
- Pancreatitis
- Nonneoplastic cysts
- Neoplasms
- Selected readings
- 20. The kidney
- Clinical manifestations of renal diseases
- Glomerular diseases
- Tubular and interstitial diseases
- Vascular diseases
- Congenital and developmental anomalies
- Cystic diseases of the kidney
- Urinary tract obstruction (obstructive uropathy)
- Urolithiasis (renal calculi, stones)
- Neoplasms of the kidney
- Selected readings
- 21. The lower urinary tract and male genital system
- The lower urinary tract
- Ureters
- Urinary bladder
- Urethra
- The male genital tract
- Penis
- Testis and epididymis
- Prostate
- Selected readings
- 22. The female genital tract
- Infections
- Vulva
- Bartholin cyst
- Nonneoplastic epithelial disorders
- Benign exophytic lesions
- Squamous neoplastic lesions
- Glandular neoplastic lesions
- Vagina
- Developmental anomalies
- Premalignant and malignant neoplasms of the vagina
- Cervix
- Inflammations
- Endocervical polyps
- Premalignant and malignant neoplasms of the cervix
- Uterine corpus
- Endometrial histology in the menstrual cycle
- Functional endometrial disorders (dysfunctional uterine bleeding)
- Inflammatory disorders
- Endometriosis and adenomyosis
- Endometrial polyps
- Endometrial hyperplasia
- Malignant tumors of the endometrium
- Tumors of endometrial stroma
- Tumors of the myometrium
- Fallopian tubes
- Ovaries
- Nonneoplastic and functional cysts
- Ovarian tumors
- Gestational and placental disorders
- Disorders of first and early second trimester gestations
- Disorders of mid to late second trimester gestations
- Disorders of the third trimester, peripartum, and puerperium
- Gestational trophoblastic disease
- Selected readings
- 23. The breast
- Disorders of development
- Clinical presentations of breast disease
- Inflammatory disorders
- Benign epithelial proliferations and precursor lesions
- Carcinoma in situ
- Invasive carcinoma of the breast
- Stromal tumors
- Other malignant tumors of the breast
- Selected readings
- 24. The endocrine system
- Pituitary gland
- Clinical manifestations of pituitary disease
- Pituitary neuroendocrine tumors and hyperpituitarism
- Hypopituitarism
- Posterior pituitary syndromes
- Hypothalamic suprasellar tumors
- Thyroid gland
- Hyperthyroidism
- Hypothyroidism
- Thyroiditis
- Graves disease
- Diffuse and multinodular goiter
- Neoplasms of the thyroid
- Congenital anomalies
- Parathyroid glands
- Hyperparathyroidism
- Hypoparathyroidism
- Endocrine pancreas
- Diabetes mellitus
- Pancreatic neuroendocrine neoplasms
- Adrenal glands
- Adrenal cortex
- Adrenal medulla
- Multiple endocrine neoplasia syndromes
- Multiple endocrine neoplasia, type 1
- Multiple endocrine neoplasia, type 2
- Pineal gland
- Acknowledgment
- Selected readings
- 25. The skin
- More than a mechanical barrier
- Disorders of pigmentation and melanocytes
- Benign epithelial tumors
- Adnexal (appendage) tumors
- Premalignant and malignant epidermal tumors
- Tumors of the dermis
- Tumors of cellular migrants to the skin
- Disorders of epidermal maturation
- Acute inflammatory dermatoses
- Chronic inflammatory dermatoses
- Blistering (bullous) diseases
- Disorders of epidermal appendages
- Panniculitis
- Infection
- Selected readings
- 26. Bones, joints, and soft tissue tumors
- Bone
- Basic structure and function of bone
- Developmental disorders of bone and cartilage
- Metabolic diseases of bone
- Fractures
- Osteonecrosis (avascular necrosis)
- Osteomyelitis
- Bone tumors
- Joints
- Arthritis
- Joint tumors
- Soft tissue tumors
- Tumors of adipose tissue
- Fibrous tumors
- Skeletal muscle tumors
- Smooth muscle tumors
- Tumors of uncertain origin
- Selected readings
- 27. Peripheral nerves and skeletal muscles
- Diseases of peripheral nerves
- Diseases of the neuromuscular junction
- Diseases of skeletal muscle
- Peripheral nerve sheath tumors
- Selected readings
- 28. The central nervous system
- Cellular pathology of the central nervous system
- Cerebral edema, hydrocephalus, raised intracranial pressure, and herniation
- Malformations and developmental disorders
- Cerebrovascular disease
- Trauma
- Perinatal brain injury
- Infections
- Demyelinating diseases
- Neurodegenerative diseases
- Genetic metabolic diseases
- Toxic and acquired metabolic diseases
- Tumors
- Selected readings
- 29. The eye
- Orbit
- Eyelid
- Conjunctiva
- Sclera
- Cornea
- Anterior segment
- Uvea
- Retina and vitreous
- Optic nerve
- The end-stage eye: Phthisis bulbi
- Selected readings
- Index