Principles and Practice of Movement Disorders

Name: Principles and Practice of Movement Disorders
Price: 12690 ISK
Availability: InStock
Author: Joseph Jankovic; Mark Hallett; Michael S Okun; Cynthia L. Comella; Stanley Fahn
ISBN: 9780323315982

Höfundar: Joseph Jankovic; Mark Hallett; Michael S Okun; Cynthia L. Comella; Stanley Fahn (Útgáfa: 3)

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Offering a state-of-the-art, authoritative summary of the most relevant scientific and clinical advances in the field, Principles and Practice of Movement Disorders provides the expert guidance you need to diagnose and manage the full range of these challenging conditions. Superb summary tables, a large video library, and a new, easy-to-navigate format help you find information quickly and apply it in your practice.

Based on the authorsâ€™ popular Aspen Course of Movement Disorders in conjunction with the International Parkinson and Movement Disorder Society, this 3rd Edition is an indispensable resource for movement disorder specialists, general neurologists, and neurology residents. Explores all facets of movement disorders, including the latest rating scales for clinical research, neurochemistry, clinical pharmacology, genetics, clinical trials, and experimental therapeutics.

Provides the essential information you need for a clinical approach to diagnosis and management, with minimal emphasis on basic science. Reflects recent advances in areas such as the genetics of Parkinsonian and other movement disorders, diagnostic brain imaging, new surgical approaches to patients with movement disorders, and new treatment guidelines for conditions such as restless legs syndrome.

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Útgefandi: Elsevier Limited (UK)

ISBN: 9780323315982

Print ISBN: 9780323310710

Format: ePub

Útgáfa: 3

Höfundar: Joseph Jankovic; Mark Hallett; Michael S Okun; Cynthia L. Comella; Stanley Fahn

Tungumál: English

Útgefið: 2021-06-11

Prent takmörkun á líftíma: 10

Flokkar: Heilbrigðisvísindi

Efnisflokkar: Læknisfræði › Taugasjúkdómafræði

Kaflar

Cover image
Title page
Table of Contents
Copyright
Video Table of Contents
Dedication
Preface
List of Illustrations
List of Tables
Chapter 1: Clinical overview and phenomenology of movement disorders
Fundamentals
Differential diagnosis of hypokinesias
Evaluation of a dyskinesia
Differential diagnosis of the hyperkinesias (dyskinesias)
The Clinical Approach to Differentiate the Dyskinesias
Conclusions
Chapter 2: Motor control: Physiology of voluntary and involuntary movements
Segmental inputs onto the alpha motoneuron
Supraspinal control of the alpha motoneuron
The basal ganglia
Parkinson disease
Dystonia
Dyskinesias
Cerebellum
Ataxia
Cortical control mechanisms
Apraxia
Voluntary movement
Disorders of willed movement
Chapter 3: Functional neuroanatomy of the basal ganglia
Introduction
Neurotransmitters
Components of the basal ganglia
Circuitry of the basal ganglia
Physiology
Chapter 4: Parkinsonism: Clinical features and differential diagnosis
Introduction
Clinical features
Clinical rating scales and other assessments
Clinical-pathophysiologic-pathologic correlations of motor parkinsonian features
Clinical heterogeneity of Parkinson disease
Natural history and progression
Epidemiology
Genetics
Pathologic findings
Ancillary tests
Presymptomatic diagnosis and biomarkers
Differential diagnosis
Chapter 5: Etiology and pathogenesis of Parkinson disease
Anatomical and biochemical pathologic processes of PD
Genetics as an etiologic factor of PD
Environmental factors that increase or decrease the risk for developing PD
Endogenous factors in dopamine neurons that contribute to the cause of PD: alpha-synuclein, cytosolic dopamine, and calcium
Where does the pathologic process of PD begin? And how does it progress? Braak staging system
Clues on pathogenesis from monogenic PD
Lewy bodies in fetal dopaminergic neurons; rogue protein hypothesis; is PD a prion-like disorder?
Multiple-hit hypothesis with a central role of alpha-synuclein
Chapter 6: Medical treatment of the motor features of Parkinson disease
Introduction
PD disease-modifying treatments
Therapeutic choices available for PD
Medications available for PD
Treatment of early-stage PD (mild symptoms, no threat to activities; these patients would be good candidates to participate in neuroprotective trials)
Treatment of mild-stage PD (when symptoms and signs begin to interfere with activities of daily living)
Treatment of moderate-stage PD (when there is an inadequate response to non-levodopa medications)
Treatment of advanced-stage PD (when there are motor complications from medications or when there is falling, freezing, or marked postural change)
Chapter 7: Surgical treatment of Parkinson disease and other movement disorders
Introduction
Functional anatomy of the basal ganglia
Techniques of stereotactic surgery
Ablative lesions of the thalamus, pallidum, and subthalamic nucleus
Gamma knife
Deep brain stimulation
Deep brain stimulation for hyperkinetic and other disorders
The future of DBS
Brain grafting
Chapter 8: Nonmotor Problems in Parkinson Disease
Introduction
Sensory symptoms
Autonomic dysfunctions: bladder and sexual problems
Other autonomic symptoms
Respiratory distress
Difficulties at night and daytime sleepiness
Fatigue
Depression, anxiety, and change in personality
Cognitive problems
Dementia and confusion
Compulsive behaviors
Psychosis: hallucinations and paranoia
Quality of life
Chapter 9: Atypical parkinsonism, parkinsonism-plus syndromes and secondary parkinsonian disorders
Introduction
Multiple system atrophy
Progressive supranuclear palsy
Corticobasal degeneration
Parkinsonism—dementia syndromes
Heredodegenerative parkinsonism
Secondary parkinsonism
Chapter 10: Tremors
Introduction
Assessment of tremors
Rest tremors
Postural tremors
Kinetic tremors
Pathophysiologic mechanisms of rest and action tremors
Other tremors
Appendix
Chapter 11: Dystonia: Phenomenology, classification, etiology, pathology, biochemistry, and genetics
Historical highlights
Phenomenology of dystonic movements
Classification
Epidemiology
Genetics: isolated and combined dystonia
Dopa-responsive dystonia
Myoclonus–dystonia
Rapid-onset dystonia–parkinsonism
Dystonia with underlying cause
Other combined dystonias
Pathophysiology
Pathoanatomy
Biochemistry
Neuroimaging
Chapter 12: Treatment of dystonia
Introduction
Physical rehabilitation for dystonia
Dopaminergic therapies
Anticholinergic therapy
Other pharmacologic therapies
Botulinum toxin
Surgical treatment of dystonia
Other therapies
Appendix
Chapter 13: Huntington disease
Introduction
Epidemiology
Clinical Aspects
Assessments
Natural course
Neuroimaging
Neuropathology and neurochemistry
Genetics
Animal models
Pathogenesis
Treatment
Experimental therapeutics
Appendix
Chapter 14: Chorea, Ballism, and Athetosis
Introduction
Dentatorubral-pallidoluysian atrophy and Huntington disease–like disorders
Other Huntington disease–like disorders
Neuroacanthocytosis
Neurodegeneration with brain iron accumulation
Other familial choreas
Infectious chorea
Postinfectious and autoimmune choreas
Other autoimmune choreas
Other choreas
Treatment of chorea
Ballism
Athetosis
Appendix
Chapter 15: Tics and Tourette syndrome
Introduction
Phenomenology of tics
Clinical features of Tourette syndrome
Pathogenesis
Genetics
Cause of tics (secondary tourettism)
Epidemiology
Treatment
Appendix
Chapter 16: Stereotypies
Introduction
Pathophysiology of stereotypies
Physiologic stereotypies
Pathologic stereotypies
Schizophrenia and catatonia
Obsessive-compulsive disorder and tic disorders
Other stereotypies
Treatment
Chapter 17: The tardive syndromes: Phenomenology, concepts on pathophysiology and treatment, and other neuroleptic-induced syndromes
Introduction
Fundamentals and definitions
Dopamine receptors and their antagonists
Atypical antipsychotics
Neurologic side effects of dopamine D2 receptor antagonists
Tardive syndromes
Treatment of tardive syndromes
Chapter 18: Myoclonus: Phenomenology, etiology, physiology, and treatment
Introduction
Classification of myoclonus
Focal myoclonus
Axial myoclonus
Multifocal and generalized cortical myoclonus
Drug treatment of generalized or multifocal myoclonus
Chapter 19: Gait disorders: Pathophysiology and clinical syndromes
Introduction
Balance
Gait
Gait disorders
Therapeutic considerations
Chapter 20: Ataxia: Pathophysiology and clinical syndromes
Introduction
Sporadic ataxia
Genetic ataxia
Diagnostic plan
Recovery from cerebellar injury; therapy
Chapter 21: Stiffness Syndromes
Introduction
Spasticity
Syndromes of continuous muscle activity
Chapter 22: Wilson disease
Wilson disease
Hereditary deficiency of ceruloplasmin
Dystonia-parkinsonism, cirrhosis, and hypermanganesemia
Chapter 23: Autoimmune Movement Disorders
Introduction
Pathogenesis
Parainfectious movement disorders
Movement disorders in autoimmune diseases
Other autoimmune disorders
Paraneoplastic movement disorders
Clinical approach and diagnosis
Therapy
Chapter 24: Paroxysmal dyskinesias
Introduction
Definitions: Transient, paroxysmal, episodic, and periodic
Historical aspects
Classification of the paroxysmal dyskinesias
Paroxysmal kinesigenic dyskinesia
Paroxysmal nonkinesigenic dyskinesia
Paroxysmal exercise-induced dyskinesia
Episodic ataxias
Molecular genetics of paroxysmal dyskinesias
Miscellany
Chapter 25: Restless legs syndrome
Restless legs syndrome and periodic movements of sleep
Chapter 26: Peripheral movement disorders
Introduction
Hemifacial spasm
Jumpy stumps
Belly dancer’s dyskinesia
Painful legs and moving toes
Focal myoclonus caused by root, plexus, or peripheral nerve lesions
Dystonia induced by peripheral injury
Muscle spasms associated with complex regional pain syndrome
Chapter 27: Functional (psychogenic) movement disorders: Phenomenology, diagnosis, and treatment
Introduction
Differential psychiatric diagnosis
Frequency
Importance of an accurate diagnosis
Physiologic basis for functional neurologic disorders
Degree of certainty of the diagnosis of a functional movement disorder
Clues suggesting the presence of a functional movement disorder
Diagnostic approach and clinical features
Treatment of functional movement disorders
Movement disorders caused by psychiatric conditions but not regarded as functional
Index