ISE Genetics: Analysis and Principles

Höfundar: Robert Brooker; Eric Widmaier; Linda Graham; Peter Stiling (Útgáfa: 8)
ISE Genetics: Analysis and Principles

Kaup valmöguleikar

Genetics: Analysis and Principles is a one-semester, introductory genetics textbook that takes an experimental approach to understanding genetics. By weaving one or two experiments into the narrative of each chapter, students can simultaneously explore the scientific method and understand the genetic principles that have been learned from these experiments. The pedagogy of Genetics: Analysis and Principles has been designed to foster student learning.

Nánar um bókina

Útgefandi
McGraw-Hill Higher Education (International)
ISBN
9781266300080
Print ISBN
9781266135828
Format
ePub
Útgáfa
8
Höfundar
Robert Brooker; Eric Widmaier; Linda Graham; Peter Stiling
Tungumál
English
Útgefið
2023-09-12
Prent takmörkun á líftíma
100
Prent takmörkun
2
Afritunar takmörkun
2

Kaflar

  • Cover
  • Title Page
  • Copyright Page
  • Brief Contents
  • Table of Contents
  • About the Authors
  • Dedication
  • Preface
  • Connect
  • unit I. Introduction
  • 1 Overview of Genetics
  • 1.1 The Molecular Expression of Genes
  • 1.2 The Relationship Between Genes and Traits
  • 1.3 Fields of Genetics
  • 1.4 The Science of Genetics
  • 1.5 Gender Identity Versus Sex
  • 1.6 The Meaning of Normal in Genetics
  • unit II. Patterns of Inheritance
  • 2 Chromosome Transmission During Cell Division and Sexual Reproduction
  • 2.1 General Features of Chromosomes
  • 2.2 Cell Division
  • 2.3 Mitosis and Cytokinesis
  • 2.4 Meiosis
  • 2.5 Sexual Reproduction
  • 2.6 Sex Chromosomes and Sex Determination
  • 3 Mendelian Inheritance
  • 3.1 Mendel’s Study of Pea Plants
  • 3.2 Law of Segregation
  • 3.3 Law of Independent Assortment
  • 3.4 The Chromosome Theory of Inheritance
  • 3.5 Studying Inheritance Patterns in Humans
  • 3.6 Probability and Statistics
  • 4 Extensions of Mendelian Inheritance
  • 4.1 Overview of Simple Inheritance Patterns
  • 4.2 Dominant and Recessive Alleles
  • 4.3 Environmental Effects on Gene Expression
  • 4.4 Incomplete Dominance, Heterozygote Advantage, and Codominance
  • 4.5 Genes on Sex Chromosomes
  • 4.6 Sex-Influenced and Sex-Limited Inheritance
  • 4.7 Lethal Alleles
  • 4.8 Understanding Complex Phenotypes Caused by Mutations in Single Genes
  • 4.9 Gene Interactions
  • 5 Non-Mendelian Inheritance
  • 5.1 Maternal Effect
  • 5.2 Epigenetics: Dosage Compensation
  • 5.3 Epigenetics: Genomic Imprinting
  • 5.4 Extranuclear Inheritance
  • 6 Genetic Linkage and Mapping in Eukaryotes
  • 6.1 Overview of Linkage
  • 6.2 Relationship Between Linkage and Crossing Over
  • 6.3 Genetic Mapping in Plants and Animals
  • 6.4 Genetic Mapping in Haploid Eukaryotes
  • 6.5 Mitotic Recombination
  • 7 Genetic Transfer and Mapping in Bacteria
  • 7.1 Overview of Genetic Transfer in Bacteria
  • 7.2 Bacterial Conjugation
  • 7.3 Conjugation and Mapping via Hfr Strains
  • 7.4 Bacterial Transduction
  • 7.5 Bacterial Transformation
  • 7.6 Medical Relevance of Horizontal Gene Transfer
  • 8 Variation in Chromosome Structure and Number
  • 8.1 Microscopic Examination of Eukaryotic Chromosomes
  • 8.2 Changes in Chromosome Structure: An Overview
  • 8.3 Deletions and Duplications
  • 8.4 Inversions and Translocations
  • 8.5 Changes in Chromosome Number: An Overview
  • 8.6 Variation in the Number of Chromosomes Within a Set: Aneuploidy
  • 8.7 Variation in the Number of Sets of Chromosomes
  • 8.8 Natural and Experimental Mechanisms That Produce Variation in Chromosome Number
  • unit III. Molecular Structure AND Replication of the Genetic Material
  • 9 Molecular Structure of DNA and RNA
  • 9.1 Identification of DNA as the Genetic Material
  • 9.2 Overview of DNA and RNA Structure
  • 9.3 Nucleotide Structure
  • 9.4 Structure of a DNA Strand
  • 9.5 Discovery of the Double Helix
  • 9.6 Structure of the DNA Double Helix
  • 9.7 RNA Structure
  • 10 Molecular Structure of Chromosomes and Transposable elements
  • 10.1 Organization of Functional Sites Along Prokaryotic Chromosomes
  • 10.2 Structure of Prokaryotic Chromosomes
  • 10.3 Organization of Functional Sites Along Eukaryotic Chromosomes
  • 10.4 Sizes of Eukaryotic Genomes and Repetitive Sequences
  • 10.5 Transposition
  • 10.6 Structure of Eukaryotic Chromosomes in Nondividing Cells
  • 10.7 Structure of Eukaryotic Chromosomes During Cell Division
  • 11 DNA Replication
  • 11.1 Structural Overview of DNA Replication
  • 11.2 Bacterial DNA Replication: The Formation of Two Replication Forks at the Origin of Replication
  • 11.3 Bacterial DNA Replication: Synthesis of New DNA Strands
  • 11.4 Bacterial DNA Replication: Chemistry and Accuracy
  • 11.5 Eukaryotic DNA Replication
  • unit IV. Molecular Properties of Genes
  • 12 Gene Transcription and RNA Modification
  • 12.1 Overview of Transcription
  • 12.2 Transcription in Bacteria
  • 12.3 Transcription in Eukaryotes
  • 12.4 RNA Modification
  • 12.5 A Comparison of Transcription and RNA Modification in Bacteria, Archaea, and Eukaryotes
  • 13 Translation of mRNA
  • 13.1 The Genetic Basis for Protein Synthesis
  • 13.2 The Relationship Between the Genetic Code and Protein Synthesis
  • 13.3 Experimental Determination of the Genetic Code
  • 13.4 Structure and Function of tRNA
  • 13.5 Ribosome Structure and Assembly
  • 13.6 Stages of Translation
  • 13.7 Regulation of Translation
  • 13.8 A Comparison of Translation in Bacteria, Archaea, and Eukaryotes
  • 14 Gene Regulation in Bacteria
  • 14.1 Overview of Transcriptional Regulation
  • 14.2 Regulation of the lac Operon
  • 14.3 Regulation of the trp Operon
  • 14.4 Translational and Posttranslational Regulation
  • 14.5 Riboswitches
  • 15 Gene Regulation in Eukaryotes I: General Features of Transcriptional Regulation
  • 15.1 Regulatory Transcription Factors and Enhancers
  • 15.2 Chromatin Remodeling, Histone Variants, and Histone Modifications
  • 15.3 DNA Methylation
  • 15.4 Gene Activation and Gene Repression
  • 15.5 A Comparison of Transcriptional Regulation in Bacteria, Archaea, and Eukaryotes
  • 16 Gene Regulation in Eukaryotes II: Epigenetics
  • 16.1 Overview of Epigenetics
  • 16.2 Heterochromatin: Function, Structure, Formation, and Maintenance
  • 16.3 Epigenetics and Development
  • 16.4 Paramutation
  • 16.5 Epigenetics and Environmental Agents
  • 17 Non-coding RNAs
  • 17.1 Overview of Non-coding RNAs
  • 17.2 Non-coding RNAs: Effects on Chromatin Structure and Transcription
  • 17.3 Non-coding RNAs: Effects on Translation and mRNA Degradation
  • 17.4 Non-coding RNAs: Effects on RNA Modifications
  • 17.5 Non-coding RNAs and Protein Targeting
  • 17.6 Non-coding RNAs and Genome Defense
  • 17.7 Role of Non-coding RNAs in Human Diseases and Plant Health
  • 18 Genetics of Viruses
  • 18.1 Virus Structure and Genetic Composition
  • 18.2 Overview of Viral Reproductive Cycles
  • 18.3 Bacteriophage λ Reproductive Cycles
  • 18.4 HIV Reproductive Cycle
  • 19 Gene Mutation, DNA Repair, and Recombination
  • 19.1 Effects of Mutations on Gene Structure and Function
  • 19.2 Random Nature of Mutations
  • 19.3 Spontaneous Mutations
  • 19.4 Induced Mutations
  • 19.5 DNA Repair
  • 19.6 Homologous Recombination
  • unit V. Genetic Technologies
  • 20 MOLECULAR Technologies
  • 20.1 Gene Cloning Using Vectors
  • 20.2 Polymerase Chain Reaction
  • 20.3 DNA Sequencing
  • 20.4 Gene Editing via CRISPR-Cas Technology
  • 20.5 Blotting Methods to Detect Gene Products
  • 20.6 Methods for Analyzing DNA- and RNA-Binding Proteins
  • 21 Biotechnology
  • 21.1 Uses of Microorganisms in Biotechnology
  • 21.2 Vaccines
  • 21.3 Genetically Modified Animals
  • 21.4 Reproductive Cloning and Stem Cells
  • 21.5 Genetically Modified Plants
  • 22 Genomics I: Analysis of DNA
  • 22.1 Overview of Chromosome Mapping
  • 22.2 Cytogenetic Mapping via Microscopy
  • 22.3 Linkage Mapping Via Crosses
  • 22.4 Chromosome Walking and Primer Walking
  • 22.5 Overview of Genome Sequencing
  • 22.6 Genome-Sequencing Projects
  • 22.7 Metagenomics
  • 23 Genomics II: Functional Genomics, Proteomics, and Bioinformatics
  • 23.1 Functional Genomics
  • 23.2 Proteomics
  • 23.3 Bioinformatics I: Overview of Computer Analyses and Gene Prediction
  • 23.4 Bioinformatics II: Databases
  • 23.5 Bioinformatics III: Homology
  • unit VI. Genetic Analysis of Individuals and Populations
  • 24 Medical Genetics
  • 24.1 Inheritance Patterns of Genetic Diseases
  • 24.2 Detection of Disease-Causing Alleles via Haplotypes and via Genome-Wide Association Studies
  • 24.3 Genetic Testing and Screening
  • 24.4 Prions
  • 24.5 Human Gene Therapy
  • 24.6 Personalized Medicine
  • 25 Genetic Basis of Cancer
  • 25.1 Overview of Cancer
  • 25.2 Oncogenes
  • 25.3 Tumor-Suppressor Genes
  • 25.4 Role of Epigenetics in Cancer
  • 25.5 Cancer Therapeutics
  • 26 Developmental genetics
  • 26.1 Overview of Animal Development
  • 26.2 Invertebrate Development
  • 26.3 Vertebrate Development
  • 26.4 Plant Development
  • 26.5 Sex Determination in Animals
  • 27 Population Genetics
  • 27.1 Genes in Populations and the Hardy-Weinberg Equation
  • 27.2 An Introduction to Microevolution
  • 27.3 Overview of Natural Selection
  • 27.4 Patterns of Natural Selection
  • 27.5 Genetic Drift
  • 27.6 Migration
  • 27.7 Nonrandom Mating
  • 27.8 Sources of New Genetic Variation
  • 28 COMPLEX AND Quantitative TRAITS
  • 28.1 Overview of Complex and Quantitative Traits
  • 28.2 Statistical Methods for Evaluating Quantitative Traits
  • 28.3 Polygenic Inheritance
  • 28.4 Identification of Genes That Control Quantitative Traits
  • 28.5 Heritability
  • 28.6 Selective Breeding
  • 29 Evolutionary Genetics
  • 29.1 Overview of Evolution
  • 29.2 Identification of Species and Mechanisms of Reproductive Isolation
  • 29.3 Speciation
  • 29.4 Phylogenetic Trees
  • 29.5 Molecular Evolution
  • Appendix A: Experimental Techniques
  • Appendix B: Solutions to Even-Numbered Problems and All Comprehension and Concept Check Questions
  • Glossary
  • Index