Introduction to Pharmaceutical Analytical Chemistry

Höfundar: Stig Pedersen-Bjergaard; Bente Gammelgaard; Trine G. Halvorsen (Útgáfa: 3)
Introduction to Pharmaceutical Analytical Chemistry

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Primary source for learning pharmaceutical analytical chemistry, fully updated and revised to reflect current practice and Pharmacopoeia standards Introduction to Pharmaceutical Analytical Chemistry enables students to gain fundamental knowledge of the vital concepts, techniques, and applications of the chemical analysis of pharmaceutical substances, final pharmaceutical products, and drug substances in biological fluids.

Extensively revised throughout to reflect the current European Pharmacopoeia (Ph. Eur. ) and United States Pharmacopeia (USP), this Third Edition presents updated methodologies, practical examples, and calculations to reflect current pharmaceutical laboratory practice. Revisions to the chapter structure, text, and figures have been implemented to improve clarity and comprehension. New practice problems, up-to-date practical examples, and detailed illustrations are also included throughout the text.

Written by a team of experienced academics, Introduction to Pharmaceutical Analytical Chemistry explores topics including: Pharmacopoeias and the link between pharmaceuticals and analytical chemistryFundamentals of bases, acids, solubility, polarity, partition, and stereochemistryTitration, UV-Vis spectrophotometry, IR spectrophotometry, and atomic spectrometry High-performance liquid chromatography, gas chromatography, electrophoretic methods, and mass spectrometryQuantitation, quality of analytical data, and validation Chemical analysis of pharmaceutical substances and products including biopharmaceuticalsSample preparation and determination of pharmaceutical substance in biological samples Introduction to Pharmaceutical Analytical Chemistry is essential reading for undergraduate and graduate students enrolled in pharmaceutical courses, along with chemists, biochemists, and other scientists entering the pharmaceutical industry.

Nánar um bókina

Útgefandi
Wiley Global Research (STMS)
ISBN
9781394263318
Print ISBN
9781394263301
Format
ePub
Útgáfa
3
Höfundar
Stig Pedersen-Bjergaard; Bente Gammelgaard; Trine G. Halvorsen
Tungumál
English
Útgefið
2025-11-05
Prent takmörkun á líftíma
100
Prent takmörkun
10
Afritunar takmörkun
2

Kaflar

  • Cover
  • Table of Contents
  • Title Page
  • Copyright
  • Preface to the Third Edition
  • Symbols and Units
  • Chapter 1: The Link Between Pharmaceuticals and Analytical Chemistry
  • 1.1 PHARMACEUTICAL PRODUCTS
  • 1.2 MANUFACTURE OF PHARMACEUTICAL SUBSTANCES
  • 1.3 MANUFACTURE OF PHARMACEUTICAL PRODUCTS
  • 1.4 DRUG DISCOVERY AND DEVELOPMENT
  • 1.5 REGULATORY SYSTEM
  • 1.6 USE OF PHARMACEUTICAL PRODUCTS
  • 1.7 PHARMACEUTICAL ANALYTICAL CHEMISTRY – A DEFINITION
  • 1.8 TEXTBOOK SCOPE
  • Chapter 2: The Link between Pharmaceutical Substances and Pharmacopoeias
  • 2.1 IMPURITIES IN PHARMACEUTICAL SUBSTANCES
  • 2.2 PHARMACOPOEIA MONOGRAPHS FOR ACTIVE SUBSTANCES AND EXCIPIENTS
  • 2.3 PHARMACOPOEIA MONOGRAPHS FOR PHARMACEUTICAL PRODUCTS
  • 2.4 PHARMACOPOEIA METHODS OF ANALYSIS AND REAGENTS
  • Chapter 3: Chemical and Physicochemical Properties of Pharmaceutical Substances and Reagents
  • 3.1 ACIDS, BASES, PH and pKa
  • 3.2 BUFFER SOLUTIONS
  • 3.3 ACID AND BASE PROPERTIES OF ACTIVE SUBSTANCES
  • 3.4 SOLUBILITY OF ACTIVE SUBSTANCES
  • 3.5 DISTRIBUTION BETWEEN PHASES
  • 3.6 ISOMERS
  • 3.7 ACTIVE SUBSTANCES – A FEW MORE EXAMPLES
  • Chapter 4: Fundamentals of Pharmaceutical Analytical Chemistry
  • 4.1 PROCEDURES IN PHARMACEUTICAL ANALYTICAL CHEMISTRY
  • 4.2 HOW TO SPECIFY QUANTITIES, CONCENTRATIONS AND COMPOSITIONS OF MIXTURES
  • 4.3 LABORATORY EQUIPMENT
  • 4.4 HOW TO MAKE SOLUTIONS AND DILUTIONS
  • 4.5 ERRORS, ACCURACY AND PRECISION
  • 4.6 STATISTICAL TESTS
  • 4.7 LINEAR REGRESSION ANALYSIS
  • 4.8 HOW TO PRESENT AN ANALYTICAL RESULT
  • Chapter 5: Titration
  • 5.1 THE PRINCIPLE OF TITRATION
  • 5.2 AQUEOUS ACID–BASE TITRATIONS
  • 5.3 POTENTIOMETRIC TITRATION AND ELECTRODES
  • 5.4 ACID–BASE TITRATION IN NON‐AQUEOUS SOLVENTS
  • 5.5 NITROGEN DETERMINATION (KJELDAHL METHOD)
  • 5.6 REDOX TITRATIONS
  • 5.7 KARL–FISCHER TITRATION
  • 5.8 OTHER TITRATION PRINCIPLES
  • Chapter 6: Introduction to Spectroscopic Methods
  • 6.1 ELECTROMAGNETIC RADIATION
  • 6.2 MOLECULES AND ABSORPTION OF ELECTROMAGNETIC RADIATION
  • 6.3 ABSORBING STRUCTURES – CHROMOPHORES
  • 6.4 FLUORESCENCE
  • 6.5 ATOMS AND ELECTROMAGNETIC RADIATION
  • Chapter 7: UV‐Vis Spectrophotometry
  • 7.1 QUANTITATION
  • 7.2 ABSORBANCE DEPENDENCE ON MEASUREMENT CONDITIONS
  • 7.3 IDENTIFICATION
  • 7.4 INSTRUMENTATION
  • 7.5 PRACTICAL WORK AND METHOD DEVELOPMENT
  • 7.6 TEST OF SPECTROPHOTOMETERS AND CUVETTES
  • 7.7 FLUORIMETRY
  • Chapter 8: Infrared Spectrophotometry
  • 8.1 BASIC PRINCIPLE
  • 8.2 INSTRUMENTATION
  • 8.3 RECORDING BY TRANSMISSION, DIFFUSE REFLECTANCE, AND ATTENUATED TOTAL REFLECTION
  • 8.4 INSTRUMENT CALIBRATION
  • 8.5 NEAR‐INFRARED (NIR) SPECTROPHOTOMETRY
  • Chapter 9: Atomic Spectrometry
  • 9.1 ATOMIC ABSORPTION SPECTROMETRY
  • 9.2 AAS INSTRUMENTATION
  • 9.3 AAS PRACTICAL WORK AND METHOD DEVELOPMENT
  • 9.4 ATOMIC EMISSION SPECTROMETRY
  • 9.5 FLAME PHOTOMETRY
  • 9.6 INDUCTIVELY COUPLED PLASMA EMISSION SPECTROMETRY
  • 9.7 INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY
  • Chapter 10: Introduction to Chromatography
  • 10.1 GENERAL PRINCIPLES AND DEFINITIONS
  • 10.2 RETENTION
  • 10.3 EFFICIENCY
  • 10.4 SELECTIVITY
  • 10.5 RESOLUTION
  • 10.6 PEAK SYMMETRY
  • 10.7 THE DYNAMICS OF CHROMATOGRAPHY
  • Chapter 11: Separation Principles in Liquid Chromatography
  • 11.1 CHROMATOGRAPHIC SEPARATION
  • 11.2 REVERSED‐PHASE CHROMATOGRAPHY
  • 11.3 ION‐PAIR CHROMATOGRAPHY
  • 11.4 NORMAL‐PHASE CHROMATOGRAPHY
  • 11.5 THIN‐LAYER CHROMATOGRAPHY
  • 11.6 HYDROPHILIC INTERACTION LIQUID CHROMATOGRAPHY
  • 11.7 ION‐EXCHANGE CHROMATOGRAPHY
  • 11.8 SIZE EXCLUSION CHROMATOGRAPHY
  • 11.9 CHIRAL SEPARATIONS
  • 11.10 SUPERCRITICAL FLUID CHROMATOGRAPHY
  • Chapter 12: High‐Performance Liquid Chromatography
  • 12.1 CHROMATOGRAPHIC SYSTEM
  • 12.2 COLUMNS
  • 12.3 SCALING BETWEEN COLUMNS
  • 12.4 PUMPS
  • 12.5 INJECTORS
  • 12.6 DETECTORS
  • 12.7 MOBILE PHASES
  • 12.8 SOLVENTS FOR SAMPLE PREPARATION
  • Chapter 13: Gas Chromatography
  • 13.1 BASIC PRINCIPLE
  • 13.2 INSTRUMENTATION
  • 13.3 CARRIER GAS
  • 13.4 STATIONARY PHASES
  • 13.5 RETENTION
  • 13.6 COLUMNS
  • 13.7 INJECTION
  • 13.8 DETECTORS
  • 13.9 DERIVATIZATION
  • Chapter 14: Electrophoretic Methods
  • 14.1 PRINCIPLE AND THEORY
  • 14.2 CAPILLARY ELECTROPHORESIS
  • 14.3 SLAB GEL ELECTROPHORESIS
  • 14.4 SDS‐PAGE
  • 14.5 WESTERN BLOTTING
  • 14.6 ISOELECTRIC FOCUSING
  • Chapter 15: Mass Spectrometry
  • 15.1 THE MASS SPECTROMETER
  • 15.2 BASIC THEORY OF MASS SPECTROMETRY
  • 15.3 IONIZATION METHODS
  • 15.4 MASS ANALYSERS
  • 15.5 QUANTITATION BY MS
  • 15.6 IDENTIFICATION BY MS
  • Chapter 16: Sample Preparation
  • 16.1 MAIN STRATEGIES IN SAMPLE PREPARATION
  • 16.2 RECOVERY AND ENRICHMENT
  • 16.3 LIQUID–LIQUID EXTRACTION
  • 16.4 SOLID–LIQUID EXTRACTION
  • 16.5 SOLID‐PHASE EXTRACTION
  • Chapter 17: Data Quality, Quantification and Validation
  • 17.1 CALIBRATION METHODS
  • 17.2 ANALYTICAL PROCEDURES
  • 17.3 VALIDATION
  • 17.4 SYSTEM SUITABILITY
  • Chapter 18: Chemical Analysis of Pharmaceutical Substances
  • 18.1 IDENTIFICATION
  • 18.2 IMPURITY TESTS
  • 18.3 ASSAY
  • 18.4 CHEMICAL ANALYSIS OF FATS, OILS, WAXES, RESINS AND RELATED PHARMACEUTICAL EXCIPIENTS
  • Chapter 19: Chemical Analysis of Pharmaceutical Products
  • 19.1 IDENTIFICATION OF THE ACTIVE SUBSTANCE
  • 19.2 ASSAY
  • 19.3 CHEMICAL TESTS FOR PHARMACEUTICAL PRODUCTS
  • Chapter 20: Bioanalysis
  • 20.1 BIOLOGICAL FLUIDS: COMPOSITION, SAMPLE COLLECTION AND STORAGE
  • 20.2 SAMPLE PREPARATION
  • 20.3 SEPARATION AND DETECTION IN PHARMACEUTICAL BIOANALYSIS
  • 20.4 QUANTITATION
  • 20.5 SCREENING
  • Chapter 21: Chemical Analysis of Biopharmaceuticals
  • 21.1 AMINO ACIDS, PEPTIDES AND PROTEINS
  • 21.2 BIOPHARMACEUTICALS VERSUS SMALL MOLECULE PHARMACEUTICALS
  • 21.3 BIOPHARMACEUTICALS AND PHARMACOPOEIAS
  • 21.4 PRODUCTION OF BIOPHARMACEUTICALS
  • 21.5 IDENTIFICATION PROCEDURES FOR BIOPHARMACEUTICAL ACTIVE SUBSTANCES
  • 21.6 IMPURITY TESTS FOR BIOPHARMACEUTICAL ACTIVE SUBSTANCES
  • 21.7 ASSAY OF BIOPHARMACEUTICAL ACTIVE SUBSTANCES
  • 21.8 ANALYSIS OF BIOPHARMACEUTICAL PRODUCTS
  • 21.9 BIOANALYSIS OF BIOPHARMACEUTICALS USING LC–MS/MS
  • Index
  • End User License Agreement