Immunology for Medical Students

Höfundur: Matthew Buckland (Útgáfa: 4)
Immunology for Medical Students

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Immunology for Medical Students provides concise yet comprehensive information for medical students about the basic science of the human immune system, and how to apply this to clinical practice. The book provides a detailed overview of how the immune system works, covers physiology, innate and adaptive immunity and the immune system in health and disease. Readers will learn how to assess a patient with an immune problem and understand from first principles the diagnosis and management of immune disorders.

This popular book is an ideal companion for medical school courses and has been fully updated to include the latest science on immunotherapies. Clear and concise – designed with the needs of busy medical students in mind – just the right amount of detail for your courseCovers the latest scientific and clinical knowledge in the fieldDetailed illustrations help the reader grasp the concepts of immunologyDetailed clinical cases demonstrate real-world applicationsTechnical boxes point out important scientific advancesEnd-of-chapter checklists of learning points facilitate reviewUpdates in basic scienceNew immunotherapies added e.

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Útgefandi
Elsevier Limited (UK)
ISBN
9780702084355
Print ISBN
9780702084348
Format
ePub
Útgáfa
4
Höfundar
Matthew Buckland
Tungumál
English
Útgefið
2025-08-08
Prent takmörkun á líftíma
10

Kaflar

  • Title of Book
  • Cover image
  • Title page
  • Table of Contents
  • Any screen, Any time, Anywhere
  • Copyright
  • Foreword
  • Preface
  • Preface to the Fourth Edition
  • Preface to the Third Edition
  • Preface to the Second Edition
  • Preface to the First Edition
  • Acknowledgments
  • How to Use This Book
  • Section 1: Introduction
  • 1. Introduction to the Immune System
  • SUMMARY
  • 2. Basic Concepts and Components of the Immune System
  • INNATE IMMUNITY
  • ADAPTIVE IMMUNITY
  • COMPONENTS OF THE IMMUNE SYSTEM
  • ACTIVE AND PASSIVE IMMUNITY
  • PHASES OF AN IMMUNE RESPONSE
  • TYPES OF IMMUNE RESPONSE
  • SUMMARY
  • Section 2: Antigen-Recognition Molecules
  • 3. Introduction to Antigen Recognition
  • ANTIGEN RECOGNITION MOLECULES
  • B-CELL AND T-CELL RECEPTORS
  • MAJOR HISTOCOMPATIBILITY COMPLEX MOLECULES
  • SUMMARY
  • 4. Antigens and Antibody Structure
  • ANTIGENS
  • ANTIBODIES
  • SUMMARY
  • 5. Antibody-Antigen Interaction
  • ANTIGEN-BINDING SITES OF ANTIBODIES
  • DIAGNOSTIC TESTS FOR ANTIBODY OR ANTIGEN
  • SUMMARY
  • 6. Antibody Diversity
  • IMMUNOGLOBULIN GENES
  • IMMUNOGLOBULIN CLASSES
  • SUMMARY
  • 7. The T-Cell Receptor
  • STRUCTURE OF THE T-CELL RECEPTOR
  • GENERATION OF DIVERSITY OF THE T-CELL RECEPTOR GENES
  • RECOGNITION OF ANTIGEN
  • OTHER ACCESSORY MOLECULES INVOLVED IN T-CELL FUNCTION
  • SUMMARY
  • 8. Major Histocompatibility Complex
  • GENETIC ORGANIZATION
  • REGULATION OF GENE EXPRESSION
  • STRUCTURE OF THE MAJOR HISTOCOMPATIBILITY COMPLEX GENE PRODUCTS
  • RESTRICTION OF ANTIGEN RECOGNITION
  • POPULATION ADVANTAGES OF POLYMORPHISM IN THE MAJOR HISTOCOMPATIBILITY COMPLEX
  • DISEASE CORRELATIONS
  • SUMMARY
  • 9. Review of Antigen Recognition
  • IMPORTANT STRUCTURAL FEATURES
  • GENERATION OF DIVERSITY
  • Section 3: Physiology
  • 10. Antigen Processing and Presentation
  • PATHWAYS OF ANTIGEN PROCESSING
  • MECHANISMS OF ANTIGEN PROCESSING
  • EVASION OF PROCESSING PATHWAYS BY PATHOGENS
  • SUMMARY
  • 11. Lymphocyte Activation
  • ANTIGEN RECEPTORS
  • SIGNALING EVENTS
  • AMPLIFICATION THROUGH SIGNALING PATHWAYS
  • RESPONSE
  • SUMMARY
  • 12. Hematopoiesis
  • THREE MAJOR STAGES OF HEMATOPOIESIS
  • LYMPHOID CELLS
  • MYELOID CELLS
  • SUMMARY
  • 13. Organs and Tissues of the Immune System
  • PRIMARY AND SECONDARY LYMPHOID ORGANS
  • LYMPHOCYTE TRAFFICKING
  • SUMMARY
  • 14. B-Cell Development
  • EARLY B-LYMPHOCYTE DEVELOPMENT
  • THE MATURE B CELL
  • SOMATIC MUTATION AND CLASS SWITCHING IN GERMINAL CENTERS
  • THYMUS-INDEPENDENT ANTIGENS
  • B1 B CELLS AND NATURAL ANTIBODIES
  • SUMMARY
  • 15. T-Cell Development
  • THE THYMUS
  • THE PERIPHERY: NAIVE T-CELL ACTIVATION BY ANTIGEN
  • SUMMARY
  • 16. T-Cell Interactions and T-Cell Help
  • GENERATION OF STIMULATED, OR PRIMED, B AND T CELLS
  • GENERATION OF EFFECTOR CELLS
  • PROVIDING THE MOST APPROPRIATE IMMUNE RESPONSE FOR A GIVEN PATHOGEN
  • SUMMARY
  • 17. Immunologic Memory and Homeostasis
  • LONG-TERM IMMUNOLOGIC MEMORY
  • LYMPHOCYTE HOMEOSTASIS
  • APOPTOSIS
  • SUMMARY
  • 18. Regulation of the Immune System
  • TOLERANCE
  • SUMMARY
  • 19. Brief Review of Immune Physiology
  • INTEGRATED IMMUNE SYSTEM: CONNECTIONS BETWEEN ADAPTIVE AND INNATE RESPONSES
  • Section 4: Innate Immunity
  • 20. Constitutive Defenses Including Complement
  • BARRIERS TO INFECTION
  • EXTRACELLULAR MOLECULES OF THE INNATE IMMUNE SYSTEM
  • SUMMARY
  • 21. Phagocytes
  • PHAGOCYTIC CELL TYPES
  • PHAGOCYTE PRODUCTION
  • PHAGOCYTE RECRUITMENT
  • RECEPTORS ON PHAGOCYTES
  • MOLECULAR PATTERNS
  • ACTIONS OF PHAGOCYTES
  • PHAGOCYTE DEFECTS
  • MOLECULAR RECOGNITION BY THE INNATE AND ADAPTIVE IMMUNE SYSTEMS
  • SUMMARY
  • 22. Killing in the Immune System
  • RESPONSE TO PARASITE WORMS
  • MAST CELLS
  • NATURAL KILLER CELLS
  • INTRACELLULAR MECHANISMS OF APOPTOSIS
  • SUMMARY
  • 23. Inflammation
  • TYPES OF INFLAMMATION
  • CYTOKINE NETWORK IN INFLAMMATION
  • TUBERCULOSIS
  • HEPATITIS B INFECTION
  • “OVERZEALOUS” INFLAMMATION
  • SUMMARY
  • 24. Cytokines in the Immune System
  • Overview
  • CYTOKINE RECEPTORS AND SIGNALING MOLECULES
  • REVIEW OF SOME OF THE ROLES OF CYTOKINES IN IMMUNE RESPONSES
  • CLINICAL USES FOR CYTOKINES AND CYTOKINE BLOCKADE
  • Summary
  • Section 5: Immune System in Health and Disease
  • 25. Infections and Vaccines
  • HOW ORGANISMS EVADE THE IMMUNE RESPONSEe
  • MECHANISMS OF IMMUNITY
  • Types of Vaccines
  • Vaccine Schedules
  • Summary
  • 26. Hypersensitivity Reactions
  • TYPES OF TRIGGERS FOR HYPERSENSITIVITY
  • TYPES OF HYPERSENSITIVITY REACTIONS
  • DIAGNOSIS AND TREATMENT OF HYPERSENSITIVITY
  • SUMMARY
  • 27. Immediate Hypersensitivity (Type I): Allergy
  • DEFINITIONS
  • ALLERGENS
  • DEGRANULATING CELLS
  • ANTIBODY
  • T-HELPER 2 CELLS
  • PREDISPOSITION TO ALLERGY
  • MEDIATORS OF EARLY PHASE OF ALLERGY
  • MEDIATORS OF LATE PHASE OF ALLERGY
  • TREATMENT
  • SUMMARY
  • 28. How Autoimmune Disease Develops
  • SOME AUTOIMMUNITY IS NORMAL
  • INITIATION OF AUTOIMMUNE DISEASE
  • T-CELL TOLERANCE
  • BREAKDOWN OF T-CELL TOLERANCE
  • TESTS FOR AUTOIMMUNE DISEASE
  • SUMMARY
  • 29. Antibody-Mediated Hypersensitivity (Type II)
  • IMMUNE-MEDIATED HEMOLYSIS
  • TYPE II HYPERSENSITIVITY AND ANTIBODIES THAT AFFECT CELL FUNCTION
  • SUMMARY
  • 30. Immune Complex Disease (Type III Hypersensitivity)
  • ANTIGENS IN IMMUNE COMPLEXES
  • ANTIBODIES IN IMMUNE COMPLEXES
  • CLEARANCE OF IMMUNE COMPLEXES
  • MECHANISMS OF INFLAMMATION IN IMMUNE COMPLEX DISEASE
  • IMMUNE COMPLEX DISEASE IN THE KIDNEY
  • TREATMENT OF IMMUNE COMPLEX DISEASE
  • SUMMARY
  • 31. Delayed Hypersensitivity (Type IV) and Review of Hypersensitivity Reactions
  • DELAYED HYPERSENSITIVITY REACTIONS ARE DRIVEN BY T-HELPER 1 CELLS
  • TYPE IV HYPERSENSITIVITY DISEASE
  • SUMMARY
  • 32. Primary Immunodeficiency
  • INFECTIONS PROVIDE CLUES TO THE TYPE OF IMMUNODEFICIENCY
  • CAUSES OF PRIMARY IMMUNODEFICIENCY
  • SCREENING FOR SEVERE COMBINED IMMUNE DEFICIENCY
  • DIAGNOSIS OF PRIMARY IMMUNODEFICIENCY
  • TREATMENT
  • SUMMARY
  • 33. Secondary Immunodeficiency
  • HIV INFECTION
  • OTHER SECONDARY IMMUNODEFICIENCIES
  • SUMMARY
  • 34. Transplantation
  • TRANSPLANTATION TERMINOLOGY
  • SOLID ORGAN TRANSPLANTATION
  • STEM CELL TRANSPLANTATION
  • TISSUE-TYPING TECHNIQUES
  • IMMUNOSUPPRESSIVE DRUGS
  • Xenotransplantation
  • SUMMARY
  • 35. Tumor Immunology
  • LYMPHOID TUMORS
  • IMMUNITY TO TUMORS
  • SUMMARY
  • 36. Biopharmaceuticals
  • MONOCLONAL ANTIBODIES
  • T-Cell Therapeutics
  • Recombinant Cytokines
  • SUMMARY
  • Glossary
  • Index
  • Confidence is ClinicalKey