Human Virology
Höfundar:
John Oxford; Paul Kellam; Leslie Collier (Útgáfa: 5)
Kaup valmöguleikar
Viruses are some of the simplest infectious agents on the planet, yet can cause severe and even life-threatening diseases in all forms of life - including humans. Despite relying on host cells in order to replicate, viruses can be capable of extremely rapid reproduction and very effective transmission from one person to another. Because of this, they have historically represented a significant proportion of the disease burden affecting humans, in addition to a number of new high profile diseases which have emerged in the last century.
However, on a more positive note, the only two diseases to have ever been eradicated by mankind were both viruses, giving hope that in the future more viruses can be eliminated. Human Virology provides a vivid introduction to this fascinating field, by incorporating both the molecular and clinical aspects of the subject. The general principles and properties of viruses are covered in the first part of the text, while part two provides a survey of the different virus families and the human diseases they cause.
Finally, the book concludes with some of the more practical aspects of the subject, such as immunization, antiviral chemotherapy and laboratory techniques. Throughout the text, case studies bring the subject to life by providing a unique perspective from real practicing doctors. In addition new 'hot topic' boxes have been incorporated into this edition, featuring current important areas of research.
Nánar um bókina
- Oxford University Press Academic UK
- 9780191073816
- 9780198714682
- Page Fidelity (PDF)
- 5
- John Oxford; Paul Kellam; Leslie Collier
- English
- 2016-10-14
- 100
- 2
- 2
Kaflar
- Preface to the fifth edition
- Contents at a glance
- Contents in detail
- Abbreviations
- Part 1 General principles
- 1 Virology: how it all began and where it will go next
- 1.1 Introduction
- 1.2 How viruses were discovered
- 1.3 How they were grown in the laboratory
- 1.4 Sizes and shapes
- 1.5 Replication
- 1.6 The control of viral diseases
- 1.7 How viruses have changed our world and will continue to do so
- Further reading
- Questions
- 2 General properties of viruses
- 2.1 Introduction
- 2.2 The architecture of viruses
- 2.3 Classification of viruses and practical applications
- 2.4 The nomenclature of viruses
- 2.5 The range of diseases caused by viruses
- 2.6 A little ‘non-human’ virology
- Reminders
- Further reading
- Questions
- 3 Viral replication and genetics
- 3.1 Introduction
- 3.2 A brief résumé of the molecular biology of the mammalian cell
- 3.3 Virus infection and replication in a host cell
- 3.4 Genetic variation of viruses
- Reminders
- Further reading
- Questions
- 4 How viruses cause disease
- 4.1 Introduction
- 4.2 Viral factors: pathogenicity and virulence
- 4.3 Interactions between viruses and host cells
- 4.4 The spread of viruses in the host
- 4.5 Patterns of disease
- 4.6 Shedding of virus from the host
- Reminders
- Further reading
- Questions
- 5 Resistance of the human body to virus infections
- 5.1 Introduction
- 5.2 General non-immune factors in resistance
- 5.3 Early innate immunity
- 5.4 The adaptive immune system
- 5.5 Activation of T cells and cell-mediated immunity
- 5.6 Harmful immune responses
- 5.7 Virus countermeasures to inhibit innate immunity and acquired immune responses
- 5.8 The role of the immune arms in resistance to infection versus recovery from infection
- Reminders
- Further reading
- Questions
- 6 Viruses and the community: the science and practice of epidemiology
- 6.1 Introduction
- 6.2 Definitions
- 6.3 What use is epidemiology and surveillance?
- 6.4 Epidemiological and surveillance methods
- 6.5 Serological epidemiology and surveillance
- 6.6 Factors in the spread of viral infections
- 6.7. Herd immunity
- 6.8 Hospital-acquired or nosocomial infections (HAIs)
- 6.9 The periodicity of epidemics
- 6.10 Control measures
- Reminders
- Further reading
- Questions
- Part 2 Specific viruses
- Group 1 Positive-sense singles-tranded RNA viruses
- 7 Picornaviruses: polio, hepatitis A, enterovirus, and common cold
- 7.1 Introduction
- 7.2 Properties of the viruses
- 7.3 Clinical and pathological aspects
- Reminders
- Further reading
- Questions
- 8 Astroviruses: gastroenteritis agents
- 8.1 Introduction
- 8.2 Properties of the viruses
- 8.3 Clinical and epidemiological aspects
- 8.4 Laboratory diagnosis
- Reminders
- Further reading
- Questions
- 9 Calciviruses: norovirus causing vomiting and diarrhoea
- 9.1 Introduction
- 9.2 Properties of the viruses
- 9.3 Clinical and epidemiological aspects
- Reminders
- Further reading
- Questions
- 10 Hepatitis E
- 10.1 Introduction
- 10.2 Properties of the virus
- 10.3 Clinical and pathological aspects
- Reminders
- Further reading
- Questions
- 11 Togaviruses: mosquito-borne Chikungunya and teratogenic rubella
- 11.1 Introduction
- 11.2 Properties of the togaviruses
- 11.3 Clinical and pathological aspects of alphaviruses
- 11.4 Teratogenic rubella virus
- 11.5 Clinical and pathological aspects of rubella
- 11.6 Control of rubella by MMR (mumps, measles, rubella) vaccine
- Reminders
- Further reading
- Questions
- 12 Flaviviruses: yellow fever, dengue fever, and hepatitis C
- 12.1 Introduction
- 12.2 Properties of flaviviruses
- 12.3 Clinical and pathological aspects of the flaviviruses
- 12.4 Epidemiology of flaviviruses
- 12.5 Pathogenesis of flaviviruses
- 12.6 Introduction to hepatitis C
- 12.7 Clinical and pathological aspects of hepatitis C virus infections
- 12.8 Epidemiology of hepatitis C
- Reminders
- Further reading
- Questions
- 13 Coronaviruses (including SARS CoV and MERS CoV)
- 13.1 Introduction
- 13.2 Properties of the viruses
- 13.3 Clinical and pathological aspects of coronaviruses other than SARS and MERS
- 13.4 A newly emerging coronavirus: Severe Acute Respiratory Syndrome (SARS CoV)
- 13.5 A newly emerging coronavirus: Middle East Respiratory Syndrome (MERS CoV)
- Reminders
- Further reading
- Questions
- Group 2 Negative-sense single-stranded RNA viruses
- 14 Orthomyxoviruses: influenza A, B, C
- 14.1 Introduction
- 14.2 Properties of the viruses
- 14.3 Clinical and pathological aspects
- 14.4 Prevention and cure
- Reminders
- Further reading
- Questions
- 15 Arenaviruses: Lassa and haemorrhagic fevers
- 15.1 Introduction
- 15.2 Properties of the viruses
- 15.3 Clinical and pathological aspects
- 15.4 Risk categories of patients
- Reminders
- Further reading
- Questions
- 16 Bunyaviruses: Hanta, phlebo, and nairo
- 16.1 Introduction
- 16.2 Properties of the viruses
- 16.3 Clinical and pathological aspects
- Reminders
- Further reading
- Questions
- 17 Paramyxoviruses: measles, RSV, mumps, parainfluenza, metapneumovirus, and the zoonotic henipaviru
- 17.1 Introduction
- 17.2 Properties of the viruses
- 17.3 Clinical and pathological aspects
- Reminders
- Further reading
- Questions
- 18 Filoviruses: zoonotic Marburg, and Ebola
- 18.1 Introduction
- 18.2 Properties of the viruses
- 18.3 Clinical and pathological aspects
- 18.4. Risk categories of patients
- Reminders
- Further reading
- Questions
- 19 Rabies: zoonotic rabies
- 19.1 Introduction
- 19.2 Properties of the virus
- 19.3 Clinical and pathological aspects
- Reminders
- Further reading
- Questions
- Group 3 Double-stranded RNA viruses
- 20 Reoviruses: diarrhoea-causing rotaviruses
- 20.1 Introduction
- 20.2 Properties of the viruses
- 20.3 Clinical and pathological aspects
- 20.4 Rotavirus vaccines
- Reminders
- Further reading
- Questions
- Group 4 Double-stranded DNA viruses
- 21 Polyomaviruses
- 21.1 Introduction
- 21.2 Properties of the viruses
- 21.3 Clinical and pathological aspects
- Reminders
- Further reading
- Questions
- 22 Papillomaviruses
- 22.1 Introduction
- 22.2 Properties of the viruses
- 22.3 Clinical and pathological aspects
- Reminders
- Further reading
- Questions
- 23 Herpesviruses: herpetic lesions, zoster, cancer, and encephalitis
- 23.1 Introduction
- 23.2 Properties of herpesviruses
- 23.3 Clinical aspects of HHV-1 and HHV-2
- 23.4 Clinical aspects of chicken pox/varicella-zoster (HHV-3) virus
- 23.5 Clinical aspects of cytomegalovirus (HHV-5)
- 23.6 Clinical aspects of HHV-6 and -7
- 23.7 Clinical aspects of Epstein–Barr virus (HHV-4)
- 23.8 Clinical aspects of Kaposi’s sarcoma associated herpesvirus (HHV-8, KSHV)
- Reminders
- Further reading
- Questions
- 24 Smallpox: human disease eradicated but zoonotic pox virus infections common
- 24.1 Introduction
- 24.2 Properties of the viruses
- 24.3 Clinical and pathological aspects of smallpox
- 24.4 Other poxvirus infections
- Reminders
- Further reading
- Questions
- 25 Adenovirus: respiratory, eye, and gastroenteritis viruses
- 25.1 Introduction
- 25.2 Properties of the virus
- 25.3 Clinical and pathological aspects
- Reminders
- Further reading
- Questions
- Group 5 Single-stranded DNA viruses
- 26 Parvoviruses
- 26.1 Introduction
- 26.2 Properties of the viruses
- 26.3 Clinical and pathological aspects
- Reminders
- Further reading
- Questions
- Group 6 Single-stranded positive sense RNA with an RT
- 27 Retroviruses: HIV-1 and -2 and HTLV
- 27.1 Introduction
- 27.2 Properties of HIV
- 27.3 Clinical and pathological aspects of HIV-1
- 27.4 Characteristics of the humanlentivirus HIV-2
- 27.5 Characteristics of the human delta retrovirus HLTV-I
- 27.6 Characteristics of the human delta retrovirus HTLV-II
- Reminders
- Further reading
- Questions
- Group 7 Circular double-stranded DNA viruses with an RT
- 28 Hepadnaviruses: hepatitis B and D
- 28.1 Introduction
- 28.2 Properties of hepatitis B virus
- 28.3 Clinical and pathological aspects of hepatitis B virus infections
- 28.4 Properties of hepatitis D (delta virus)
- 28.5 Clinical and pathological aspects of hepatitis delta virus infections
- Reminders
- Further reading
- Questions
- Part 3 Practical aspects
- 29 The clinical virology laboratory
- 29.1 Introduction
- 29.2 Collection and transport of clinical specimens to the laboratory: vital steps
- 29.3 Rapid diagnostic methods
- 29.4 Virus isolation in cell cultures
- 29.5 Detection of antiviral antibodies
- Reminders
- Further reading
- Questions
- 30 Control of viral diseases by immunization
- 30.1 Introduction
- 30.2 The technology and practicalities of virus vaccine production and development
- 30.3 Virus vaccines and public health
- 30.4 Passive immunization
- 30.5 New approaches to vaccine development
- Reminders
- Further reading
- Questions
- 31 Antiviral chemotherapy
- 31.1 Introduction
- 31.2 Points of action of antivirals in the virus life cycle
- 31.3 The use of antivirals: general considerations
- 31.4 Herpes infections and antivirals
- 31.5 Influenza and antivirals
- 31.6 HIV infections and antivirals
- 31.7 Clinical use of interferons
- 31.8 The future: a combination of proteomics and genetics to identify host proteins as new targets
- Reminders
- Further reading
- Questions
- Index