Genetics: From Genes To Genomes ISE

Höfundar: Michael Goldberg; Janice Fischer; Leroy Hood; Leland Hartwell (Útgáfa: 8)
Genetics: From Genes To Genomes ISE

Kaup valmöguleikar

Genetics: From Genes to Genomes represents a new approach to an undergraduate course in genetics. It reflects the way the authors currently view the molecular basis of life. The eighth edition emphasizes both the core concepts of genetics and the cutting-edge discoveries, modern tools, and analytical methods that will keep the science of genetics moving forward.

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Útgefandi
McGraw-Hill Higher Education (International)
ISBN
9781266379956
Print ISBN
9781266246678
Format
ePub
Útgáfa
8
Höfundar
Michael Goldberg; Janice Fischer; Leroy Hood; Leland Hartwell
Tungumál
English
Útgefið
2023-10-03
Prent takmörkun á líftíma
100
Prent takmörkun
2
Afritunar takmörkun
2

Kaflar

  • Cover
  • Title Page
  • Copyright Page
  • About the Authors
  • Brief Contents
  • Contents
  • Preface
  • Changes in the Eighth Edition
  • Guided Tour
  • Acknowledgments
  • Half-Title Page
  • Part I Basic Principles: How Traits Are Transmitted
  • Chapter 1 Mendel’s Principles of Heredity
  • 1.1 The Puzzle of Inheritance
  • 1.2 Genetic Analysis According to Mendel
  • 1.3 Mendelian Inheritance in Humans
  • Chapter 2 Extensions to Mendel’s Laws
  • 2.1 Extensions to Mendel for Single-Gene Inheritance
  • 2.2 Extensions to Mendel for Two-Gene Inheritance
  • 2.3 Extensions to Mendel for Complex Trait Inheritance
  • 2.4 A Comprehensive Example: Dog Coat Color Genes
  • Chapter 3 Chromosomes and Inheritance
  • 3.1 Chromosomes: The Carriers of Genes
  • ■ Genetics and Society: Prenatal Genetic Diagnosis
  • 3.2 Mitosis: Cell Division that Preserves Chromosome Number
  • 3.3 Meiosis: Cell Divisions that Halve Chromosome Number
  • Chapter 4 Sex Chromosomes
  • 4.1 Sex Chromosomes and Sex Determination
  • ■ Fast Forward: Transgenic Mice Prove that SRY Is the Maleness Factor
  • 4.2 Gametogenesis
  • 4.3 Sex Linkage
  • 4.4 Sex-Linked and Sexually Dimorphic Traits in Humans
  • ■ Fast Forward: Visualizing X-Chromosome Inactivation in Transgenic Mice
  • 4.5 Human Intersexuality
  • Chapter 5 Linkage, Recombination, and Gene Mapping
  • 5.1 Gene Linkage and Recombination
  • 5.2 Recombination: A Result of Crossing-Over During Meiosis
  • 5.3 Mapping: Locating Genes Along a Chromosome
  • ■ Fast Forward: Mapping the Crossovers that Generate the Chromosomes of Individual Human Sperm
  • ■ Fast Forward: Gene Mapping Has Led to Treatments for Cystic Fibrosis
  • 5.4 The Chi-Square Test and Linkage Analysis
  • ■ Tools of Genetics: The Chi-Square Test for Goodness of Fit
  • 5.5 Tetrad Analysis in Fungi
  • 5.6 Mitotic Recombination and Genetic Mosaics
  • ■ Genetics and Society: Mitotic Recombination and Cancer
  • Part II What Genes Are and What They Do
  • Chapter 6 DNA Structure, Replication, and Recombination
  • 6.1 Experimental Evidence for DNA as the Genetic Material
  • 6.2 The Watson and Crick Double Helix Model of DNA
  • 6.3 Genetic Information in Nucleotide Sequence
  • 6.4 DNA Replication
  • 6.5 Homologous Recombination at the DNA Level
  • 6.6 Site-Specific Recombination
  • Chapter 7 Mutation
  • 7.1 Mutations: Primary Tools of Genetic Analysis
  • 7.2 Molecular Mechanisms that Alter DNA Sequence
  • ■ Fast Forward: Trinucleotide Repeat Diseases
  • 7.3 DNA Repair Mechanisms
  • Chapter 8 Using Mutations to Understand Genes
  • 8.1 What Mutations Tell Us About Gene Structure
  • 8.2 What Mutations Tell Us About Gene Function
  • 8.3 What Mutations Tell Us About the Genetic Code
  • 8.4 A Comprehensive Example: Mutations that Affect Vision
  • Chapter 9 Gene Expression: The Flow of Information from DNA to RNA to Protein
  • 9.1 Transcription: From DNA to RNA
  • ■ Genetics and Society: HIV and Reverse Transcription
  • 9.2 Translation: From mRNA to Protein
  • 9.3 Differences in Gene Expression Between Prokaryotes and Eukaryotes
  • 9.4 The Effects of Mutations on Gene Expression and Function
  • Part III Analysis of Genetic Information
  • Chapter 10 Digital Analysis of DNA
  • 10.1 Fragmenting DNA
  • ■ Tools of Genetics: Serendipity in Science: The Discovery of Restriction Enzymes
  • 10.2 Cloning DNA Fragments
  • 10.3 Sequencing DNA
  • 10.4 Sequencing Genomes
  • Chapter 11 Genome Annotation
  • 11.1 Finding the Genes in Genomes
  • 11.2 Genome Architecture and Evolution
  • 11.3 Bioinformatics: Information Technology and Genomes
  • 11.4 A Comprehensive Example: The Hemoglobin Genes
  • Chapter 12 Analyzing Genomic Variation
  • 12.1 Variation Among Genomes
  • 12.2 Genotyping a Known Disease-Causing Mutation
  • 12.3 Sampling DNA Variation in a Genome
  • ■ Fast Forward: Genetic Genealogy
  • 12.4 Positional Cloning
  • ■ Tools of Genetics: The Lod Score Statistic
  • 12.5 The Era of Whole-Genome Sequencing
  • Part IV How Genes Travel on Chromosomes
  • Chapter 13 The Eukaryotic Chromosome
  • 13.1 Chromosomal DNA and Proteins
  • 13.2 Chromosome Structure and Compaction
  • 13.3 Chromosomal Packaging and Gene Expression
  • 13.4 Replication of Eukaryotic Chromosomes
  • 13.5 Chromosome Segregation
  • 13.6 Artificial Chromosomes
  • Chapter 14 Chromosomal Rearrangements
  • 14.1 Rearrangements of Chromosomal DNA
  • ■ Fast Forward: Programmed DNA Rearrangements and the Immune System
  • 14.2 The Effects of Rearrangements
  • 14.3 Transposable Genetic Elements
  • 14.4 Genome Restructuring and Evolution
  • Chapter 15 Ploidy
  • 15.1 Aberrations in Chromosome Number: Aneuploidy
  • 15.2 Variation in Number of Chromosome Sets: Euploidy
  • 15.3 Whole-Genome Duplication as a Driver of Evolution
  • Chapter 16 Bacterial Genetics
  • 16.1 The Enormous Diversity of Bacteria
  • 16.2 Bacterial Genomes
  • ■ Genetics and Society: The Human Microbiome Project
  • 16.3 Bacteria as Experimental Organisms
  • 16.4 Gene Transfer in Bacteria
  • 16.5 Using Genetics to Study Bacterial Life
  • 16.6 A Comprehensive Example: How N. gonorrhoeae Became Resistant to Penicillin
  • Chapter 17 Organellar Inheritance
  • 17.1 Mitochondria and Their Genomes
  • 17.2 Chloroplasts and Their Genomes
  • 17.3 The Relationship Between Organellar and Nuclear Genomes
  • 17.4 Non-Mendelian Inheritance of Mitochondria and Chloroplasts
  • 17.5 Mutant Mitochondria and Human Disease
  • ■ Fast Forward: Mitochondrial Eve
  • Part V How Genes Are Regulated
  • Chapter 18 Gene Regulation in Prokaryotes
  • 18.1 The Elements of Prokaryotic Gene Expression
  • 18.2 Regulation of Transcription Initiation via DNA-Binding Proteins
  • 18.3 RNA-Mediated Mechanisms of Gene Regulation
  • 18.4 Discovering and Manipulating Bacterial Gene Regulatory Mechanisms
  • 18.5 A Comprehensive Example: Control of Bioluminescence by Quorum Sensing
  • Chapter 19 Gene Regulation in Eukaryotes
  • 19.1 Overview of Eukaryotic Gene Regulation
  • 19.2 Control of Transcription Initiation Through Enhancers
  • ■ Tools of Genetics: The Gal4/UASG Binary Gene Expression System
  • 19.3 Regulation After Transcription
  • 19.4 A Comprehensive Example: Sex Determination in Drosophila
  • Chapter 20 Epigenetics
  • 20.1 Transcriptional Regulation Through DNA Methylation
  • 20.2 Genomic Imprinting
  • 20.3 Inheritance of Programmed Gene Repression
  • 20.4 Transgenerational Epigenetic Inheritance
  • 20.5 A Comprehensive Example: Epigenetic Inheritance at the A Locus in Mice
  • Part VI Using Genetics
  • Chapter 21 Manipulating the Genomes of Eukaryotes
  • 21.1 Creating Transgenic Organisms
  • 21.2 Uses of Transgenic Organisms
  • ■ Tools of Genetics: Cloning by Somatic Cell Nuclear Transfer
  • 21.3 Targeted Mutagenesis
  • ■ Tools of Genetics: How Bacteria Use CRISPR/Cas9 to Vaccinate Themselves Against Viruses
  • 21.4 Human Gene Therapy
  • ■ Genetics and Society: Should We Alter Human Germ-Line Genomes?
  • Chapter 22 Genetic Analysis of Development
  • 22.1 Model Organisms: Prototypes for Developmental Genetics
  • 22.2 Mutagenesis Screens
  • 22.3 Determining Where and When Genes Act
  • 22.4 Ordering Genes in a Pathway
  • 22.5 A Comprehensive Example: Body Plan Development in Drosophila
  • Chapter 23 The Genetics of Cancer
  • 23.1 Characteristics of Cancer Cells
  • 23.2 The Genetic Basis of Cancers
  • 23.3 How Cell Division Is Normally Controlled
  • ■ Tools of Genetics: Analysis of Cell-Cycle Mutants in Yeast
  • 23.4 How Mutations Cause Cancer
  • 23.5 Personalized Cancer Treatment
  • Part VII Beyond the Individual Gene and Genome
  • Chapter 24 Variation and Selection in Populations
  • 24.1 The Hardy-Weinberg Law: Predicting Genetic Variation in “Ideal” Populations
  • 24.2 What Causes Allele Frequencies to Change in Real Populations?
  • 24.3 Ancestry and the Evolution of Modern Humans
  • Chapter 25 Genetic Analysis of Complex Traits
  • 25.1 Heritability: Genetic Versus Environmental Influences on Complex Traits
  • 25.2 Mapping Quantitative Trait Loci (QTLs)
  • ■ Tools of Genetics: The Chi-Square Test for Independence
  • Guidelines for Gene Nomenclature
  • Brief Answers to Odd-Numbered Problems
  • Glossary
  • Index