Genetics: From Genes To Genomes ISE

Höfundar: Michael Goldberg; Janice Fischer; Leroy Hood; Leland Hartwell (Útgáfa: 8)
Genetics: From Genes To Genomes ISE

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Útgefandi
McGraw-Hill Higher Education (International)
ISBN
9781266379956
Print ISBN
9781266246678
Format
ePub
Útgáfa
8
Höfundar
Michael Goldberg; Janice Fischer; Leroy Hood; Leland Hartwell
Tungumál
English
Útgefið
2023-10-03
Prent takmörkun á líftíma
100
Prent takmörkun
2
Afritunar takmörkun
2

Kaflar

  • Cover
  • Title Page
  • Copyright Page
  • About the Authors
  • Brief Contents
  • Contents
  • Preface
  • Changes in the Eighth Edition
  • Guided Tour
  • Acknowledgments
  • Half-Title Page
  • Part I Basic Principles: How Traits Are Transmitted
  • Chapter 1 Mendel’s Principles of Heredity
  • 1.1 The Puzzle of Inheritance
  • 1.2 Genetic Analysis According to Mendel
  • 1.3 Mendelian Inheritance in Humans
  • Chapter 2 Extensions to Mendel’s Laws
  • 2.1 Extensions to Mendel for Single-Gene Inheritance
  • 2.2 Extensions to Mendel for Two-Gene Inheritance
  • 2.3 Extensions to Mendel for Complex Trait Inheritance
  • 2.4 A Comprehensive Example: Dog Coat Color Genes
  • Chapter 3 Chromosomes and Inheritance
  • 3.1 Chromosomes: The Carriers of Genes
  • ■ Genetics and Society: Prenatal Genetic Diagnosis
  • 3.2 Mitosis: Cell Division that Preserves Chromosome Number
  • 3.3 Meiosis: Cell Divisions that Halve Chromosome Number
  • Chapter 4 Sex Chromosomes
  • 4.1 Sex Chromosomes and Sex Determination
  • ■ Fast Forward: Transgenic Mice Prove that SRY Is the Maleness Factor
  • 4.2 Gametogenesis
  • 4.3 Sex Linkage
  • 4.4 Sex-Linked and Sexually Dimorphic Traits in Humans
  • ■ Fast Forward: Visualizing X-Chromosome Inactivation in Transgenic Mice
  • 4.5 Human Intersexuality
  • Chapter 5 Linkage, Recombination, and Gene Mapping
  • 5.1 Gene Linkage and Recombination
  • 5.2 Recombination: A Result of Crossing-Over During Meiosis
  • 5.3 Mapping: Locating Genes Along a Chromosome
  • ■ Fast Forward: Mapping the Crossovers that Generate the Chromosomes of Individual Human Sperm
  • ■ Fast Forward: Gene Mapping Has Led to Treatments for Cystic Fibrosis
  • 5.4 The Chi-Square Test and Linkage Analysis
  • ■ Tools of Genetics: The Chi-Square Test for Goodness of Fit
  • 5.5 Tetrad Analysis in Fungi
  • 5.6 Mitotic Recombination and Genetic Mosaics
  • ■ Genetics and Society: Mitotic Recombination and Cancer
  • Part II What Genes Are and What They Do
  • Chapter 6 DNA Structure, Replication, and Recombination
  • 6.1 Experimental Evidence for DNA as the Genetic Material
  • 6.2 The Watson and Crick Double Helix Model of DNA
  • 6.3 Genetic Information in Nucleotide Sequence
  • 6.4 DNA Replication
  • 6.5 Homologous Recombination at the DNA Level
  • 6.6 Site-Specific Recombination
  • Chapter 7 Mutation
  • 7.1 Mutations: Primary Tools of Genetic Analysis
  • 7.2 Molecular Mechanisms that Alter DNA Sequence
  • ■ Fast Forward: Trinucleotide Repeat Diseases
  • 7.3 DNA Repair Mechanisms
  • Chapter 8 Using Mutations to Understand Genes
  • 8.1 What Mutations Tell Us About Gene Structure
  • 8.2 What Mutations Tell Us About Gene Function
  • 8.3 What Mutations Tell Us About the Genetic Code
  • 8.4 A Comprehensive Example: Mutations that Affect Vision
  • Chapter 9 Gene Expression: The Flow of Information from DNA to RNA to Protein
  • 9.1 Transcription: From DNA to RNA
  • ■ Genetics and Society: HIV and Reverse Transcription
  • 9.2 Translation: From mRNA to Protein
  • 9.3 Differences in Gene Expression Between Prokaryotes and Eukaryotes
  • 9.4 The Effects of Mutations on Gene Expression and Function
  • Part III Analysis of Genetic Information
  • Chapter 10 Digital Analysis of DNA
  • 10.1 Fragmenting DNA
  • ■ Tools of Genetics: Serendipity in Science: The Discovery of Restriction Enzymes
  • 10.2 Cloning DNA Fragments
  • 10.3 Sequencing DNA
  • 10.4 Sequencing Genomes
  • Chapter 11 Genome Annotation
  • 11.1 Finding the Genes in Genomes
  • 11.2 Genome Architecture and Evolution
  • 11.3 Bioinformatics: Information Technology and Genomes
  • 11.4 A Comprehensive Example: The Hemoglobin Genes
  • Chapter 12 Analyzing Genomic Variation
  • 12.1 Variation Among Genomes
  • 12.2 Genotyping a Known Disease-Causing Mutation
  • 12.3 Sampling DNA Variation in a Genome
  • ■ Fast Forward: Genetic Genealogy
  • 12.4 Positional Cloning
  • ■ Tools of Genetics: The Lod Score Statistic
  • 12.5 The Era of Whole-Genome Sequencing
  • Part IV How Genes Travel on Chromosomes
  • Chapter 13 The Eukaryotic Chromosome
  • 13.1 Chromosomal DNA and Proteins
  • 13.2 Chromosome Structure and Compaction
  • 13.3 Chromosomal Packaging and Gene Expression
  • 13.4 Replication of Eukaryotic Chromosomes
  • 13.5 Chromosome Segregation
  • 13.6 Artificial Chromosomes
  • Chapter 14 Chromosomal Rearrangements
  • 14.1 Rearrangements of Chromosomal DNA
  • ■ Fast Forward: Programmed DNA Rearrangements and the Immune System
  • 14.2 The Effects of Rearrangements
  • 14.3 Transposable Genetic Elements
  • 14.4 Genome Restructuring and Evolution
  • Chapter 15 Ploidy
  • 15.1 Aberrations in Chromosome Number: Aneuploidy
  • 15.2 Variation in Number of Chromosome Sets: Euploidy
  • 15.3 Whole-Genome Duplication as a Driver of Evolution
  • Chapter 16 Bacterial Genetics
  • 16.1 The Enormous Diversity of Bacteria
  • 16.2 Bacterial Genomes
  • ■ Genetics and Society: The Human Microbiome Project
  • 16.3 Bacteria as Experimental Organisms
  • 16.4 Gene Transfer in Bacteria
  • 16.5 Using Genetics to Study Bacterial Life
  • 16.6 A Comprehensive Example: How N. gonorrhoeae Became Resistant to Penicillin
  • Chapter 17 Organellar Inheritance
  • 17.1 Mitochondria and Their Genomes
  • 17.2 Chloroplasts and Their Genomes
  • 17.3 The Relationship Between Organellar and Nuclear Genomes
  • 17.4 Non-Mendelian Inheritance of Mitochondria and Chloroplasts
  • 17.5 Mutant Mitochondria and Human Disease
  • ■ Fast Forward: Mitochondrial Eve
  • Part V How Genes Are Regulated
  • Chapter 18 Gene Regulation in Prokaryotes
  • 18.1 The Elements of Prokaryotic Gene Expression
  • 18.2 Regulation of Transcription Initiation via DNA-Binding Proteins
  • 18.3 RNA-Mediated Mechanisms of Gene Regulation
  • 18.4 Discovering and Manipulating Bacterial Gene Regulatory Mechanisms
  • 18.5 A Comprehensive Example: Control of Bioluminescence by Quorum Sensing
  • Chapter 19 Gene Regulation in Eukaryotes
  • 19.1 Overview of Eukaryotic Gene Regulation
  • 19.2 Control of Transcription Initiation Through Enhancers
  • ■ Tools of Genetics: The Gal4/UASG Binary Gene Expression System
  • 19.3 Regulation After Transcription
  • 19.4 A Comprehensive Example: Sex Determination in Drosophila
  • Chapter 20 Epigenetics
  • 20.1 Transcriptional Regulation Through DNA Methylation
  • 20.2 Genomic Imprinting
  • 20.3 Inheritance of Programmed Gene Repression
  • 20.4 Transgenerational Epigenetic Inheritance
  • 20.5 A Comprehensive Example: Epigenetic Inheritance at the A Locus in Mice
  • Part VI Using Genetics
  • Chapter 21 Manipulating the Genomes of Eukaryotes
  • 21.1 Creating Transgenic Organisms
  • 21.2 Uses of Transgenic Organisms
  • ■ Tools of Genetics: Cloning by Somatic Cell Nuclear Transfer
  • 21.3 Targeted Mutagenesis
  • ■ Tools of Genetics: How Bacteria Use CRISPR/Cas9 to Vaccinate Themselves Against Viruses
  • 21.4 Human Gene Therapy
  • ■ Genetics and Society: Should We Alter Human Germ-Line Genomes?
  • Chapter 22 Genetic Analysis of Development
  • 22.1 Model Organisms: Prototypes for Developmental Genetics
  • 22.2 Mutagenesis Screens
  • 22.3 Determining Where and When Genes Act
  • 22.4 Ordering Genes in a Pathway
  • 22.5 A Comprehensive Example: Body Plan Development in Drosophila
  • Chapter 23 The Genetics of Cancer
  • 23.1 Characteristics of Cancer Cells
  • 23.2 The Genetic Basis of Cancers
  • 23.3 How Cell Division Is Normally Controlled
  • ■ Tools of Genetics: Analysis of Cell-Cycle Mutants in Yeast
  • 23.4 How Mutations Cause Cancer
  • 23.5 Personalized Cancer Treatment
  • Part VII Beyond the Individual Gene and Genome
  • Chapter 24 Variation and Selection in Populations
  • 24.1 The Hardy-Weinberg Law: Predicting Genetic Variation in “Ideal” Populations
  • 24.2 What Causes Allele Frequencies to Change in Real Populations?
  • 24.3 Ancestry and the Evolution of Modern Humans
  • Chapter 25 Genetic Analysis of Complex Traits
  • 25.1 Heritability: Genetic Versus Environmental Influences on Complex Traits
  • 25.2 Mapping Quantitative Trait Loci (QTLs)
  • ■ Tools of Genetics: The Chi-Square Test for Independence
  • Guidelines for Gene Nomenclature
  • Brief Answers to Odd-Numbered Problems
  • Glossary
  • Index