Fundamental Molecular Biology

Name: Fundamental Molecular Biology
Price: 5190 ISK
Availability: InStock
Author: Lizabeth A. Allison
ISBN: 9781119156321

Höfundur: Lizabeth A. Allison (Útgáfa: 3)

Kaup valmöguleikar

While there is an innate fascination and interest in how our own genes influence our lives, molecular biology students are daunted by the amount of information they need to assimilate in order to succeed in the course. And, with the fast pace of discovery in the field, it is difficult to find suitable, up to date texts for the course-they are either too advanced, comprehensive and overwhelming detailed, or they are too basic, superficial, and less experimental in their approach.

Instructors find it difficult to decide what topics are the most important to include and exclude in the course when presented with an extensive array of choices. Fundamental Molecular Biology is selective in its coverage and presents essential topics that allow students to develop an understanding of how molecular biology is applied to the analysis of complex systems. Through the process of discovery-- observations, questions, experimental designs, results and conclusions-and with an emphasis on the language of molecular biology, students can focus on the key ideas they need to succeed in the course.

Students will also have the support they need outside the classroom to leave your course knowing the core, fundamental concepts of molecular biology delivered through a visually engaging, and focused text with a rich media program that promotes self-study. With a strong emphasis on biomedical research and discovery, students are exposed to both classic and the most up to date techniques and research in molecular biology today.

Nánar um bókina

Útgefandi: Wiley Global Research (STMS)

ISBN: 9781119156321

Print ISBN: 9781119156291

Format: ePub

Útgáfa: 3

Höfundar: Lizabeth A. Allison

Tungumál: English

Útgefið: 2021-04-21

Prent takmörkun á líftíma: 100

Prent takmörkun: 10

Afritunar takmörkun: 2

Flokkar: Náttúruvísindi

Efnisflokkar: Vísindi › Frumufræði

Kaflar

Cover
Title Page
Copyright
ABOUT THE COMPANION WEBSITE
CHAPTER ONE: The Beginnings of Molecular Biology
1.1 Introduction
1.2 Insights into the nature of the hereditary material
1.3 A model for the structure of DNA: The DNA double helix
1.4 The central dogma of molecular biology
1.5 An evolutionary framework for heredity
BIBLIOGRAPHY
CHAPTER TWO: The Structure of DNA
2.1 Introduction
2.2 Primary structure: the components of nucleic acids
2.3 Secondary structure of DNA
2.4 Unusual DNA secondary structures
2.5 Tertiary structure of DNA
BIBLIOGRAPHY
CHAPTER THREE: The Versatility of RNA
3.1 Introduction
3.2 RNA is involved in a wide range of cellular processes
3.3 Structural motifs of RNA
3.4 The discovery of RNA catalysis
3.5 RNA‐based genomes
BIBLIOGRAPHY
CHAPTER FOUR: Protein Structure and Folding
4.1 Introduction
4.2 Primary structure: amino acids and the genetic code
4.3 The three‐dimensional structure of proteins
4.4 Protein function and regulation of activity
4.5 Protein folding and misfolding
BIBLIOGRAPHY
CHAPTER FIVE: Genome Organization and Evolution
5.1 Introduction
5.2 Genome organization varies in different organisms
5.3 Packaging of the eukaryotic genome
5.4 The majority of the eukaryotic genome is noncoding
5.5 Lateral gene transfer contributes to genome evolution
5.6 Prokaryotic and viral genome organization
BIBLIOGRAPHY
CHAPTER SIX: DNA Replication and Telomere Maintenance
6.1 Introduction
6.2 Early insights into the mode of bacterial DNA replication
6.3 DNA polymerases are the enzymes that catalyze DNA synthesis from 5′ to 3′
6.4 The bacterial replisome
6.5 The eukaryotic replisome
6.6 Alternative modes of circular DNA replication
6.7 Telomere maintenance: the role of telomerase in DNA replication, aging, and cancer
BIBLIOGRAPHY
CHAPTER SEVEN: DNA Repair Pathways
7.1 Introduction
7.2 Mutations and DNA damage
7.3 Lesion bypass
7.4 Direct reversal of DNA damage
7.5 Repair of single base changes and structural distortions by removal of DNA damage
7.6 Double‐strand break repair by removal of DNA damage
BIBLIOGRAPHY
CHAPTER EIGHT: Transcription in Bacteria
8.1 Introduction
8.2 Mechanism of transcription
8.3 Insights into gene regulation from the lactose (lac) operon
8.4 Mode of action of transcriptional regulators
8.5 Control of gene expression by RNA
8.6 Gene regulatory networks
BIBLIOGRAPHY
CHAPTER NINE: Transcription in Eukaryotes
9.1 Introduction
9.2 Overview of transcriptional regulation
9.3 Protein‐coding gene regulatory elements
9.4 The general transcription machinery and mechanism of transcription
9.5 The role of specific transcription factors in gene regulation
9.6 Transcriptional coactivators and corepressors
9.7 Transcription complex assembly: the enhanceosome model versus the “hit‐and‐run” model
9.8 Regulated nuclear import and export of transcription factors
BIBLIOGRAPHY
CHAPTER TEN: Epigenetic Mechanisms of Gene Regulation
10.1 Introduction
10.2 Epigenetic markers
10.3 Genomic imprinting
10.4 X chromosome inactivation
10.5 Epigenetic control of transposable elements
10.6 Epigenetics and nutritional legacy
10.7 Allelic exclusion
BIBLIOGRAPHY
CHAPTER ELEVEN: RNA Processing and Posttranscriptional Gene Regulation
11.1 Introduction
11.2 The discovery of split genes
11.3 Splicing occurs by a variety of mechanisms
11.4 Cotranscriptional processing of nuclear pre‐mRNA
11.5 Alternative splicing
11.6 RNA editing
11.7 Post‐transcriptional gene regulation by RNAi
11.8 RNA turnover in the nucleus and cytoplasm
BIBLIOGRAPHY
CHAPTER TWELVE: The Mechanism of Translation
12.1 Introduction
12.2 Ribosome structure and assembly
12.3 Aminoacyl‐tRNA synthetases
12.4 Initiation of translation
12.5 Elongation and events in the ribosome tunnel
12.6 Termination of translation
12.7 Translational and post‐translational control
BIBLIOGRAPHY
CHAPTER THIRTEEN: Recombinant DNA Technology and Genetically Modified Organisms
13.1 Introduction
13.2 The beginnings of recombinant DNA technology
13.3 Cutting and joining DNA
13.4 Molecular cloning
13.5 Library screening and probes
13.6 Restriction mapping and RFLP analysis
13.7 DNA sequencing
13.8 Introduction to genetically modified organisms
13.9 Transgenic mice: pronuclear microinjection
13.10 Gene targeting in mouse embryonic stem cells
13.11 CRISPR‐Cas gene editing
13.12 Applications of genetically modified animals
13.13 Cloning by nuclear transfer
13.14 Transgenic plants
BIBLIOGRAPHY
CHAPTER FOURTEEN: Tools for Analyzing Gene Organization, Expression, and Function
14.1 Introduction
14.2 DNA typing
14.3 Genomics, proteomics, and beyond
14.4 Whole‐genome sequencing
14.5 Reporter genes
14.6 Transcriptomics: RNA expression and localization
14.7 Proteomics: protein expression and localization
14.8 Analysis of nucleic acid–protein interactions
14.9 Analysis of protein–protein interactions
14.10 Structural analysis of proteins
BIBLIOGRAPHY
CHAPTER FIFTEEN: Medical Molecular Biology
15.1 Introduction
15.2 Genomic medicine
15.3 Molecular biology of cancer
15.4 Gene therapy
BIBLIOGRAPHY
APPENDIX
Chapter 1
Chapter 2
Chapter 3
Chapter 4
Chapter 5
Chapter 6
Chapter 7
Chapter 8
Chapter 9
Chapter 10
Chapter 11
Chapter 12
Chapter 13
Chapter 14
Chapter 15
GLOSSARY
Index
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