Cellular and Molecular Immunology

Höfundar: Abul K. Abbas, Andrew H. Lichtman, Shiv Pillai, Sarah Henrickson (Útgáfa: 11)
Cellular and Molecular Immunology

Kaup valmöguleikar

**Selected for 2025 Doody’s Core TitlesĀ® in Immunology**Well-written, readable, and superbly illustrated, Cellular and Molecular Immunology, Eleventh Edition, continues the tradition of excellence established through multiple editions of this bestselling text. Offering an unparalleled introduction to this complex field, it retains a practical, clinical focus while updating and revising all content to ensure clarity and comprehension, bringing readers fully up to date with new and emerging information in this challenging area.

It's an ideal resource for medical, graduate, and undergraduate students, as well as a trusted reference for physicians and scientists. Highlights the implications of immunologic science for the management of human disease, emphasizing clinical relevance throughout. Employs a highly accessible writing style that makes difficult concepts easier to understand, and provides clear implications of immunologic science to the management of human disease and clinical practice.

Features updates from cover to cover, including new information on COVID-19, genetics and pathogenesis of allergic diseases, newly recognized primary immune regulatory disorders, interactions between the immune system and brain and their role in CNS disorders, and CRISPR/Cas9 based gene editing. Provides a highly visual, full-color description of the key immunologic and molecular processes with a fully updated, comprehensive, and consistent art program, including many new and extensively revised illustrations.

Nánar um bókina

Útgefandi
Elsevier Limited (UK)
ISBN
9780443283598
Print ISBN
9780443283581
Format
ePub
Útgáfa
11
Höfundar
Abul K. Abbas, Andrew H. Lichtman, Shiv Pillai, Sarah Henrickson
Tungumál
English
Útgefið
2025-09-23
Prent takmörkun á líftíma
10

Kaflar

  • Title of Book
  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • Dedication
  • Preface
  • Get the Most Out of Cellular and Molecular Immunology 11e – Accompanying Electronic Resources
  • Activate your eBook today!
  • 1. Overview of the Immune System
  • OVERVIEW OF INNATE AND ADAPTIVE IMMUNITY
  • INTRODUCTION TO INNATE IMMUNITY
  • INTRODUCTION TO ADAPTIVE IMMUNITY
  • SELECTED READINGS
  • Historical Ideas
  • Evolution of the Immune System
  • New Technologies for Human Immunology
  • 2. Cells and Tissues of the Immune System
  • CELLS OF THE IMMUNE SYSTEM
  • ANATOMY AND FUNCTIONS OF LYMPHOID TISSUES
  • SUMMARY
  • SELECTED READINGS
  • Cells of the Immune System
  • Tissues of the Immune System
  • 3. Leukocyte Circulation and Migration Into Tissues
  • Overview of Leukocyte Migration
  • Adhesion Molecules on Leukocytes and Endothelial Cells Involved in Leukocyte Recruitment
  • CHEMOKINES AND CHEMOKINE RECEPTORS
  • Leukocyte-Endothelial Interactions and Leukocyte Recruitment into Tissues
  • Migration of Neutrophils and Monocytes to Sites of Infection or Tissue Injury
  • Migration and Recirculation of T Lymphocytes
  • Migration of B Lymphocytes
  • Summary
  • Selected Readings
  • Adhesion Molecules
  • Chemokines and Other Regulators of Migration
  • Lymphocyte Migration Through Lymphoid Tissues and Into Inflammatory Sites
  • 4. Innate Immunity
  • OVERVIEW OF INNATE IMMUNITY
  • RECOGNITION OF MICROBES AND DAMAGED TISSUE BY THE INNATE IMMUNE SYSTEM
  • CELLULAR PATTERN RECOGNITION RECEPTORS
  • CELLULAR COMPONENTS OF THE INNATE IMMUNE SYSTEM
  • SOLUBLE EFFECTOR MOLECULES OF INNATE IMMUNITY
  • THE INFLAMMATORY RESPONSE
  • THE ANTIVIRAL RESPONSE
  • STIMULATION OF ADAPTIVE IMMUNITY
  • MECHANISMS THAT LIMIT INNATE IMMUNE RESPONSES
  • SUMMARY
  • Selected Readings
  • History and Overview
  • Pattern Recognition
  • Soluble Effector Molecules of Innate Immunity
  • Cells of the Innate Immune System
  • Functional Responses of Innate Immunity: Inflammation, Cell Death, and Antiviral Responses
  • Diseases Caused by Innate Immune Reactions
  • 5. Antibodies And Antigens
  • Antibody Structure
  • Synthesis, Assembly, and Expression of Immunoglobulin Molecules
  • Antigens
  • Structure-Function Relationships in Antibody Molecules
  • Summary
  • SELECTED READINGS
  • Structure and Function of Antibodies
  • Antibody Production and Monoclonal Antibodies
  • Antibody Half-Life
  • Therapeutic Applications of Antibodies
  • 6. Antigen Presentation to T Lymphocytes and the Role of Major Histocompatibility Complex Molecules
  • PROPERTIES OF ANTIGENS RECOGNIZED BY T LYMPHOCYTES
  • ANTIGEN CAPTURE AND THE FUNCTIONS OF ANTIGEN-PRESENTING CELLS
  • THE MAJOR HISTOCOMPATIBILITY COMPLEX
  • PROCESSING OF PROTEIN ANTIGENS
  • PRESENTATION OF NONPROTEIN ANTIGENS TO T CELLS
  • SUMMARY
  • Selected Readings
  • The Role of Dendritic Cells in Antigen Capture and Presentation
  • Discovery of the Major Histocompatibility Complex and Its Function
  • Structure of Major Histocompatibility Complex Genes, Major Histocompatibility Complex Molecules, and Peptide-MHC Complexes
  • Protein Antigen Processing and Major Histocompatibility Complex–Associated Presentation of Peptide Antigens
  • Cross-Presentation
  • “Nonclassical” Antigen Presentation
  • 7. Immune Receptors and Signal Transduction
  • Overview of Signal Transduction
  • The Immune Receptor Family
  • The T-Cell Receptor Complex and T-Cell Signaling
  • The B-Lymphocyte Antigen Receptor Complex
  • The Attenuation of Immune Receptor Signaling
  • Cytokine Receptors and Signaling
  • Summary
  • Selected Readings
  • Signaling by Immune Receptors
  • Signal Attenuation in Lymphocytes
  • Cytokine Receptors
  • Apoptosis
  • 8. Lymphocyte Development and Antigen Receptor Gene Rearrangement
  • Overview of Lymphocyte Development
  • Rearrangement of Antigen Receptor Genes in B and T Lymphocytes
  • B-Lymphocyte Development
  • T-Lymphocyte Development
  • Summary
  • Selected Readings
  • Early B-Cell Development and V(D)J Recombination
  • T-Cell Development
  • 9. Activation and Regulation of T Lymphocytes
  • Overview of T-Lymphocyte Activation
  • Signals for T-Lymphocyte Activation
  • Functional Responses of T Lymphocytes
  • Decline of T-Cell Responses
  • Summary
  • Selected Readings
  • T-Cell Activation
  • Costimulation: B7, CD28, and More
  • T-Cell Cytokines
  • Memory T Cells
  • Differentiation and Functions of CD4+ Effector T Cells
  • Overview of CD4+ T Cell–Mediated Immune Responses
  • Subsets of CD4+ Effector T Cells
  • The Th1 Subset
  • The Th2 Subset
  • The Th17 Subset
  • Functions of Other Helper T-Cell Subsets
  • Summary
  • Selected Readings
  • Differentiation of CD4+ T Cells Into Subsets of Effector Cells: Th1, Th2, and Th17
  • Cell-Mediated Immunity: Activation of Macrophages
  • Other T-Cell Populations
  • Differentiation and Functions of CD8+ Effector T Cells
  • Differentiation of CD8+ T Cells Into Cytotoxic T Lymphocytes
  • Effector Functions of CD8+ Cytotoxic T Lymphocytes
  • Roles of CD8+ Cytotoxic T Lymphocytes in Host Defense
  • Summary
  • Selected Readings
  • Activation and Exhaustion of CD8+ T Lymphocytes
  • Mechanisms of Cytotoxic T Lymphocyte–Mediated Cytotoxicity
  • 12. B-Cell Activation and Antibody Production
  • Overview of Humoral Immune Responses
  • Antigen Recognition by B Cells and Antigen-Induced B-Cell Activation
  • Helper T Cell–Dependent Antibody Responses to Protein Antigens
  • Antibody Responses to T-Independent Antigens
  • Antibody Feedback: Regulation of Humoral Immune Responses by Fc Receptors
  • Summary
  • Selected Readings
  • B-Cell Subsets and B-Cell Activation
  • T Follicular Helper Cells and the Germinal Center Reaction
  • Activation-Induced Deaminase, Class Switching, and Somatic Mutation
  • 13. Effector Mechanisms of Humoral Immunity
  • Overview of Humoral Immunity
  • Neutralization of Microbes and Microbial Toxins
  • Fc Receptor-Mediated Antibody Effector Functions
  • The Complement System
  • Summary
  • SELECTED READINGS
  • 14. Specialized Immunity at Epithelial Barriers and in Immune-Privileged Tissues
  • GENERAL FEATURES OF IMMUNITY AT EPITHELIAL BARRIERS
  • IMMUNITY IN THE GASTROINTESTINAL SYSTEM
  • IMMUNITY IN OTHER MUCOSAL TISSUES
  • THE CUTANEOUS IMMUNE SYSTEM
  • INTERACTIONS OF THE NERVOUS AND IMMUNE SYSTEMS
  • IMMUNE-PRIVILEGED TISSUES
  • IMMUNITY IN THE MAMMALIAN FETUS AND NEWBORN
  • SUMMARY
  • SELECTED READINGS
  • Gastrointestinal Immune System
  • Antibody Production in the Gastrointestinal Immune System
  • Respiratory Mucosal Immune System
  • Skin Immune System
  • Other Specialized Immune Systems
  • 15. Immunologic Tolerance and Autoimmunity
  • Overview of Immunologic Tolerance
  • T-Lymphocyte Tolerance
  • B-Lymphocyte Tolerance
  • Tolerance to the Fetus, Commensal Microbes, and Other Foreign Antigens
  • Mechanisms of Autoimmunity
  • Summary
  • SELECTED READINGS
  • Immunologic Tolerance and General Mechanisms
  • Central Tolerance
  • Regulatory T Cells
  • Anergy
  • Apoptosis
  • Mechanisms of Autoimmunity: General Concepts
  • Mechanisms of Autoimmunity: Genetics
  • Mechanisms of Autoimmunity: Environmental Factors
  • 16. Immunity to Microbes
  • OVERVIEW OF IMMUNE RESPONSES TO MICROBES
  • IMMUNITY TO EXTRACELLULAR BACTERIA
  • IMMUNITY TO INTRACELLULAR BACTERIA
  • IMMUNITY TO FUNGI
  • IMMUNITY TO VIRUSES
  • IMMUNITY TO PARASITES
  • STRATEGIES FOR VACCINE DEVELOPMENT
  • SUMMARY
  • SELECTED READINGS
  • 17. Transplantation Immunology
  • IMMUNE RESPONSES TO ALLOGRAFTS
  • PATTERNS AND MECHANISMS OF ALLOGRAFT REJECTION
  • PREVENTION AND TREATMENT OF ALLOGRAFT REJECTION
  • XENOGENEIC TRANSPLANTATION
  • BLOOD TRANSFUSION AND THE ABO AND Rh BLOOD GROUP ANTIGENS
  • HEMATOPOIETIC STEM CELL TRANSPLANTATION
  • SUMMARY
  • SELECTED READINGS
  • Recognition and Rejection of Allogeneic Transplants
  • Clinical Transplantation
  • Immunosuppression and Tolerance Induction to Allografts
  • Xenotransplantation
  • Blood Group Antigens
  • 18. Tumor Immunology
  • OVERVIEW OF TUMOR IMMUNITY
  • TUMOR ANTIGENS
  • IMMUNE RESPONSES TO TUMORS
  • EVASION OF IMMUNE RESPONSES BY TUMORS
  • IMMUNOTHERAPY FOR TUMORS
  • SUMMARY
  • SELECTED READINGS
  • Tumor Immunity: General
  • Tumor Immunotherapy
  • 19. Hypersensitivity Disorders
  • CAUSES OF HYPERSENSITIVITY DISEASES
  • MECHANISMS AND CLASSIFICATION OF HYPERSENSITIVITY REACTIONS
  • DISEASES CAUSED BY ANTIBODIES AND ANTIGEN-ANTIBODY COMPLEXES
  • DISEASES CAUSED BY T LYMPHOCYTES
  • THERAPEUTIC APPROACHES FOR IMMUNOLOGIC DISEASES
  • SELECTED IMMUNOLOGIC DISEASES: PATHOGENESIS AND THERAPEUTIC STRATEGIES
  • SUMMARY
  • SELECTED READINGS
  • General
  • Antibody- and Immune Complex-Mediated Disorders
  • T Cell–Mediated Disorders
  • Systemic Lupus Erythematosus
  • Rheumatoid Arthritis
  • Multiple Sclerosis
  • Type 1 Diabetes
  • Other Immunologic Diseases
  • 20. Allergy
  • Overview of IgE-Dependent Allergic Reactions
  • Production of IgE
  • Cells Involved in Allergic Reactions
  • Reactions Dependent on IgE and Mast Cells
  • Development of Allergic Disease
  • Allergic Diseases in Humans: Pathogenesis and Therapy
  • The Protective Roles of Immune Reactions Mediated by IgE and Mast Cells
  • Summary
  • Selected Readings
  • Mast Cells and Eosinophils
  • Immune Responses Underlying Atopic Disorders
  • Allergic Diseases
  • 21. Congenital and Acquired Immunodeficiencies
  • OVERVIEW OF IMMUNODEFICIENCIES
  • INBORN ERRORS OF IMMUNITY
  • Defects in Innate Immunity
  • Defects in Adaptive Immunity
  • Secondary (Acquired) Immunodeficiencies
  • Human Immunodeficiency Virus and Acquired Immunodeficiency Syndrome
  • SUMMARY
  • SELECTED READINGS
  • Congenital (Inborn) Errors of Immunity
  • HIV and AIDS
  • Glossary
  • Appendix I. Principal Features of Selected CD Molecules
  • Appendix 1O. Review Questions and Answers
  • Chapter 1: Overview of the Immune System
  • Chapter 2: Cells and Tissues of the Immune System
  • Chapter 3: Leukocyte Circulation and Migration Into Tissues
  • Chapter 4: Innate Immunity
  • Chapter 5: Antibodies and Antigens
  • Chapter 6: Antigen Presentation to T Lymphocytes and the Role of Major Histocompatibility Complex Molecules
  • Chapter 7: Immune Receptors and Signal Transduction
  • Chapter 8: Lymphocyte Development and Antigen Receptor Gene Rearrangement
  • Chapter 9: Activation and Regulation of T Lymphocytes
  • Chapter 10: Differentiation and Functions of CD4+ Effector T Cells
  • Chapter 11: Differentiation and Functions of CD8+ Effector T Cells
  • Chapter 12: B-Cell Activation and Antibody Production
  • Chapter 13: Effector Mechanisms of Humoral Immunity
  • Chapter 14: Specialized Immunity at Epithelial Barriers and in Immune-Privileged Tissues
  • Chapter 15: Immunologic Tolerance and Autoimmunity
  • Chapter 16: Immunity to Microbes
  • Chapter 17: Transplantation Immunology
  • Chapter 18: Tumor Immunology
  • Chapter 19: Hypersensitivity Disorders
  • Chapter 20: Allergy
  • Chapter 21: Congenital and Acquired Immunodeficiencies
  • Appendix II. Cytokines
  • Appendix 2O
  • Chapter 1: Properties and Overview of Immune Responses
  • Chapter 2: Cells and Tissues of the Immune System
  • Chapter 3: Leukocyte Migration Into Tissues
  • Chapter 4: Innate Immunity
  • Chapter 5: Antibodies and Antigens
  • Chapter 6: Major Histocompatibility Complex Molecules and Antigen Presentation to T Lymphocytes
  • Chapter 7: Immune Receptors and Signal Transduction
  • Chapter 8: Lymphocyte Development and Antigen Receptor Gene Rearrangement
  • Chapter 9: Activation of T Lymphocytes
  • Chapter 10: Differentiation and Functions of CD4+ Effector T Cells
  • Chapter 11: Differentiation and Functions of CD8+ Effector T Cells
  • Chapter 12: B-Cell Activation and Antibody Production
  • Chapter 13: Effector Mechanisms of Humoral Immunity
  • Chapter 14: Regional Immunity: Specialized Immune Responses in Epithelial and Immune-Privileged Tissues
  • Chapter 15: Immunologic Tolerance and Autoimmunity
  • Chapter 16: Immunity to Microbes
  • Chapter 17: Transplantation Immunology
  • Chapter 18: Immunity to Tumors
  • Chapter 19: Hypersensitivity Disorders
  • Chapter 20: IgE-Dependent Immune Responses and Allergic Disease
  • Chapter 21: Congenital and Acquired Immunodeficiencies
  • Appendix III. Laboratory Techniques Commonly Used in Immunology
  • Laboratory Methods Using Antibodies
  • Transgenic Mice and Gene Targeting
  • Methods for Studying T Lymphocyte Responses
  • Methods for Studying B Lymphocyte Responses
  • Clinical Diagnostic Applications of Immunologic Assays
  • Appendix 3O. Clinical Cases
  • Case 1: Lymphoma
  • Case 2: Heart Transplantation Complicated by Allograft Rejection
  • Case 3: Allergic Asthma
  • Case 4: Systemic Lupus Erythematosus
  • Case 5: Human Immunodeficiency Virus Infection: Acquired Immunodeficiency Syndrome
  • Case 6: SARS-CoV-2 Infection: COVID-19
  • Index
  • Confidence is ClinicalKey