Aulton's Pharmaceutics

Name: Aulton's Pharmaceutics
Price: 4290 ISK
Availability: InStock
Author: Kevin M. G. Taylor, Michael E. Aulton
ISBN: 9780443287879

Höfundar: Kevin M. G. Taylor, Michael E. Aulton (Útgáfa: 7)

Kaup valmöguleikar

Aulton's Pharmaceutics, 7th Edition hefur verið endurskoðuð ítarlega, uppfærð og aukin af sérfræðingum á viðkomandi fræðasviðum, undir ritstjórn prófessoranna Kevin Taylor og Michael Aulton. Bókin fjallar á heildstæðan hátt um fræði og framkvæmd lyfjaformunar, lyfjaframleiðslu og lyfjagjafar. Þessi grundvallarkennslubók í lyfjagerðarfræði nær yfir heilt námskeið og hentar nemendum á öllum árum í grunnnámi í lyfjafræði og skyldum greinum.

Bókin er einnig ómetanlegt uppflettirit fyrir framhaldsnema í lyfjavísindum, sérfræðinga í lyfjaiðnaði og tengdum atvinnugreinum, starfsfólk í tækniþjónustu sjúkrahúsapóteka og þá sem starfa að lyfjaeftirliti. Textinn er skýr og aðgengilegur og fjöldi skýringarmynda, taflna, línurita og upplýsingaramma auðveldar skilning á þessu flókna fræðasviði.

Nauðsynlegt fylgirit með öllu námi í lyfjagerðarfræði, frá fyrsta degi til námsloka, sérstaklega skrifað fyrir þá sem eru að stíga sín fyrstu skref í hönnun og framleiðslu lyfjaforma.
Uppfært efni í allri bókinni og nýir kaflar sem endurspegla framfarir í lyfjaformun, lyfjagjöf, lyfjaframleiðslu og lyfjaeftirliti.
Uppfærðar upplýsingar um COVID í tengslum við nanólyf og líftæknilyf.
Fjallað er um viðeigandi þætti lyfjavísinda, þar á meðal fræði lyfjaformunar og lyfjagjafar.
Núverandi starfshættir og framtíðarnotkun lyfjaformunar og lyfjagjafar fyrir smásameindalyf, líftækniafurðir og nanólyf.
Rammar með lykilatriðum veita fljótlegt yfirlit yfir mikilvægar upplýsingar og meira en 400 fjölvalsspurningar á netinu nýtast til sjálfsmats og upprifjunar.

Nánar um bókina

Útgefandi: Elsevier Limited (UK)

ISBN: 9780443287879

Print ISBN: 9780443287824

Format: ePub

Útgáfa: 7

Höfundar: Kevin M. G. Taylor, Michael E. Aulton

Tungumál: English

Útgefið: 2026-05-05

Prent takmörkun á líftíma: 10

Prent takmörkun: 2

Afritunar takmörkun: 2

Flokkar: Heilbrigðisvísindi

Efnisflokkar: Læknisfræði › Lyfjafræði

Kaflar

Cover image
Title page
Copyright
Preface
Acknowledgements
Contents
Contributors
What is ‘pharmaceutics’?
Chapter 1 Design of dosage forms
Chapter Contents
Principles of dosage form design
Biopharmaceutical aspects of dosage form design
Drug factors in dosage form design
Therapeutic considerations in dosage form design
Manufacture and quality assurance of medicines
Forward look
Summary
Bibliography
Part 1 Scientific principles of dosage form design
Chapter 2 Dissolution and solubility
CHAPTER CONTENTS
Key Points
Introduction
Definition of terms
Process of dissolution
Dissolution rates of solids in liquids
Solubility
Summary
Reference
Bibliography
Chapter 3 Properties of solutions
Chapter Contents
Key Points
Introduction
Types of solution
Ionization of solutes
Colligative properties
Diffusion in solution
Summary
BIBLIOGRAPHY
Chapter 4 Surfaces and interfaces
Chapter Contents
Key Points
Introduction
Surface tension
Solid wettability
Adsorption at interfaces
Solid–vapour adsorption isotherms
Interactions between powders and water vapour
Inverse phase gas chromatography
References
Chapter 5 Disperse systems
Chapter Contents
Key Points
Introduction
Colloids
Gels
Surface-active agents
Coarse disperse systems
References
Bibliography
Chapter 6 Rheology
Chapter Contents
Key Points
Viscosity, rheology and the flow of fluids
Newtonian fluids
Non-Newtonian fluids
The applications of rheology in pharmaceutical formulation
References
Bibliography
Chapter 7 Kinetics
Chapter Contents
Key Points
Introduction
Rate laws and order of reaction
Complex reactions
The Michaelis-Menten equation
Effect of temperature on reaction rate
Summary
Bibliography
Part 2 Particle science and powder technology
Chapter 8 Solid-state properties
Chapter Contents
Key Points
Solid state
Crystallization
Polymorphism
Hydrates and solvates
Amorphous state
Crystal habit
Surface nature of particles
References
Bibliography
Chapter 9 Particle size analysis
Chapter Contents
Key Points
Introduction
Particle size
Particle size analysis methods
Selection of a particle size analysis method
Reference
Bibliography
Chapter 10 Particle size reduction and size separation
Chapter Contents
Key Points
Introduction
Influence of material properties on size reduction
Influence of size reduction on size distribution
Size reduction methods
Selection of the particle size reduction method
Introduction to size separation
Size separation methods
Selection of a size separation process
Bibliography
Chapter 11 Mixing
Chapter Contents
Key Points
Mixing principles
Mechanisms of mixing and demixing
Mixing of powders
Mixing of miscible liquids and suspensions
Mixing of semisolids
References
Bibliography
Chapter 12 Powder flow
Chapter Contents
Key Points
Introduction
Particle properties
Process conditions: hopper design
Characterization of powder flow
Improvement of powder flowability
Summary
Bibliography
Part 3 Pharmaceutical microbiology and sterilization
Chapter 13 Fundamentals of microbiology
Chapter Contents
Key Points
Introduction
Viruses
Reproduction of viruses
Latent infections
Oncogenic viruses
Bacteriophages
Archaea
Bacteria
Fungi
References
Bibliography
Chapter 14 Pharmaceutical applications of microbiological techniques
Chapter Contents
Key Points
Introduction
Measurement of antimicrobial activity
Microbiological quality of pharmaceutical materials
References
Chapter 15 Action of physical and chemical agents on microorganisms
Chapter Contents
Key Points
Introduction
Kinetics of cell inactivation
Antimicrobial effects of moist and dry heat
Ionizing radiation
Ultraviolet radiation
Gases
Antimicrobial effects of chemical agents
References
Chapter 16 Principles of sterilization
Chapter Contents
Key Points
Introduction
Need for sterility
Sterilization parameters
Principles of sterilization processes
New technologies
Summary
References
Bibliography
Chapter 17 Sterilization in practice
Chapter Contents
Key Points
Sterile products
Determination of sterilization protocols
Recommended pharmacopoeial sterilization processes
High-level disinfection
Statistical considerations of sterility testing and sterility assurance level
Test for sterility of the product
Validation of a sterilization process
Limitations of sterilization methods
Summary
References
Bibliography
Part 4 Biopharmaceutical principles of drug delivery
Chapter 18 Introduction to biopharmaceutics
Chapter Contents
Key Points
What is biopharmaceutics?
Concept of bioavailability
Concept of biopharmaceutics
Summary
Bibliography
Chapter 19 Gastrointestinal tract – physiology and drug absorption
Chapter Contents
Key Points
Introduction
Physiological factors influencing oral drug absorption
Anatomy and physiology of the gastrointestinal tract
Transit of pharmaceuticals in the gastrointestinal tract
Barriers to drug absorption
Summary
References
Bibliography
Chapter 20 Bioavailability – physicochemical, dosage form and formulation factors
Chapter Contents
Key Points
Introduction
Physicochemical factors influencing bioavailability
Physiological factors affecting the dissolution rate of drugs
Drug factors affecting dissolution rate
Factors affecting the concentration of drug in solution in gastrointestinal fluids
Improving the bioavailability of drugs with poor aqueous solubility
Other formulation approaches to improving drug bioavailability
Improving the bioavailability of drugs with poor permeability
Dosage form factors influencing bioavailability
Influence of formulation excipients on drug dissolution and absorption
Summary
References
Bibliography
Chapter 21 Assessment of biopharmaceutical properties
Chapter Contents
Key Points
Introduction
Measurement of key biopharmaceutical properties
Assessment of bioavailability
Bioequivalence
Assessment at the site of release in vivo
Biopharmaceutics Classification System
Summary
References
Bibliography
Chapter 22 Dosage regimens
Chapter Contents
Key Points
Dosage regimens: influence on the plasma concentration–time profile of a drug in the body
One-compartment open model of drug disposition in the body
Important factors influencing steady-state plasma concentrations of a drug
Summary
Bibliography
Part 5 Dosage form design and manufacture
Chapter 23 Pharmaceutical preformulation
Chapter Contents
Key Points
The concept of preformulation
Assay development
Solubility
Molecular dissociation
Partitioning
Dissolution rate
Hygroscopicity
Physical form
Powder properties
Compaction properties
Summary
References
Bibliography
Chapter 24 Solutions
Chapter Contents
Key Points
Introduction
Pharmaceutical solutions
Solution stability
Enhancement of drug solubility
Bibliography
Chapter 25 Clarification
Chapter Contents
Key Points
Introduction
Filtration
Filtration equipment
Centrifugation
Bibliography
Chapter 26 Suspensions
Chapter Contents
Key Points
INTRODUCTION
Definition of a suspension
Solid particle–liquid vehicle interactions
Particle movement in suspensions
Dispersibility issues – surface wetting
Dissolution issues
Ostwald ripening
General suspension formulation considerations
Stability considerations for suspensions
Manufacturing considerations
Summary
Bibliography
Chapter 27 Emulsions and creams
Chapter Contents
Key Points
Introduction
Emulsions in pharmacy
Formulation of pharmaceutical emulsions
Emulsifying agents (emulsifiers)
Creams
Manufacture and processing of emulsions and creams
Emulsion properties
Emulsion stability
Stability testing
Bibliography
Chapter 28 Ointments, pastes, gels, cutaneous patches and topical sprays
Chapter Contents
Key Points
Introduction
Topical semisolid preparations
Ointments
Pastes
Gels
Emulgels
Cutaneous patches/medicated plasters
Topical sprays
Small-scale manufacturing (compounding) of ointments and pastes
Large-scale manufacturing of topical semisolid preparations
Regulatory requirements and testing for topical semisolid preparations
Summary
References
Bibliography
Chapter 29 Powders, granules and granulation
Chapter Contents
Key Points
Introduction
Powdered and granulated products as dosage forms
Granules used as an intermediate in tablet manufacture
Pharmaceutical technology of granule production
Granulation mechanisms
Pharmaceutical granulation equipment and processes
Bibliography
Chapter 30 Drying
Chapter Contents
Key Points
Introduction
Drying of wet solids
Types of drying method
Convective drying of wet solids
Conductive drying of wet solids
Radiation drying of wet solids
Drying of solutions and suspensions
Freeze-drying (lyophilization)
Solute migration during drying
Bibliography
Chapter 31 Tablets and compaction
Chapter Contents
Key Points
INTRODUCTION
Quality attributes of tablets
Tablet manufacturing
Tablet Excipients
Tablet types
Tablet testing
Fundamental aspects of the compression of powders
Fundamental aspects of the compaction of powders
Relationships between material properties and tablet strength
REFERENCES
BIBLIOGRAPHY
Chapter 32 Modified-release oral drug delivery
Chapter Contents
Key Points
Modified-release oral drug delivery
What modified-release drug delivery means for the patient
What modified-release drug delivery means for healthcare professionals and the pharmaceutical industry
Sites of action for modified-release dosage forms and biopharmaceutical considerations
Designing a modified-release formulation: factors to consider
Extended release
Delayed release
Three-dimensional printing
Conclusions
References
Bibliography
Chapter 33 Coating of tablets and multiparticulates
Chapter Contents
Key Points
Introduction
Film coating
Sugar coating
Compression coating
Coating of tablets
Coating of multiparticulates
References
Bibliography
Chapter 34 Continuous manufacturing of tablets
Chapter Contents
Key Points
Introduction
Batch versus continuous manufacturing
Advantages of continuous manufacturing
Drawbacks of continuous manufacturing
Continuous manufacturing processes
Process analytical technology
Real-time release testing
Regulatory considerations
Summary
References
Bibliography
Chapter 35 Hard capsules
Chapter Contents
Key Points
Introduction
Raw materials
Manufacture
Formulation
References
Bibliography
Chapter 36 Soft capsules
Chapter Contents
Key Points
Introduction
Soft capsule manufacturing
Shell polymer systems
Fill formulation
Quality considerations
Summary
References
Bibliography
Chapter 37 Dissolution testing of solid oral dosage forms
Chapter Contents
Key Points
The relevance of drug dissolution and dissolution testing
Dissolution testing
Dissolution testing for quality control
Predictive dissolution testing
Summary
References
Bibliography
Chapter 38 Parenteral drug delivery
Chapter Contents
Key Points
Introduction
Routes of parenteral administration
Pharmacopoeial requirements
Absorption from injection sites
Excipients
Containers
Bibliography
Chapter 39 Pulmonary drug delivery
Chapter Contents
Key Points
Inhaled drug delivery
Formulating and delivering therapeutic inhalation aerosols
Measuring delivered dose
Methods of aerosol size analysis
REFERENCE
BIBLIOGRAPHY
Chapter 40 Nasal drug delivery
Chapter Contents
Key Points
Introduction
Anatomy and physiology of the nose
Drug delivery
Nasal delivery systems
Summary
Bibliography
Chapter 41 Ocular drug delivery
Chapter Contents
Key Points
Introduction
Anatomy and physiology of the eye
Some common ocular conditions and pharmacological interventions
Topical ophthalmic preparations
Formulating ophthalmic preparations
Topical, liquid AND SEMISOLID ophthalmic preparations
Topical, solid ophthalmic preparations
Barriers to topical ocular drug absorption
Increasing drug solubility and absorption in topical ophthalmic preparations
Sterility of ophthalmic preparations
Ocular drug pharmacokinetics
Targeting the posterior segment of the eye
Problems with traditional and new ocular drug delivery systems
Patient adherence and instillation of eye drops
References
Bibliography
Chapter 42 Otic drug delivery
Chapter Contents
Key Points
Introduction
Anatomy and physiology of the ear
Barriers to otic drug delivery
Major ear diseases and therapies
Administration routes for otic drug delivery
Formulations for otic drug delivery systems
Progress and challenges in otic drug delivery
Summary
Bibliography
Chapter 43 Topical and transdermal drug delivery
Chapter Contents
Key Points
Introduction
Skin structure and function
Transport through the skin
Experimental methods for studying transdermal drug delivery
Transdermal and topical preparations
Enhancement of transdermal and topical drug delivery
Nail delivery
Bibliography
Chapter 44 Rectal and vaginal drug delivery
Chapter Contents
Key Points
Introduction
Rectal drug delivery
Rectal dosage forms
Vaginal drug delivery
Vaginal dosage forms
Manufacture of rectal and vaginal dosage forms
Quality control of rectal and vaginal dosage forms
References
Bibliography
Chapter 45 Preparation and delivery of biopharmaceuticals
Chapter Contents
Key Points
Introduction
Monoclonal antibody–based therapeutics
Nucleic acid drugs
Engineered cell-based therapies
Vaccines
Hormones
Challenges in biopharmaceutical delivery
Formulation and delivery strategies for biopharmaceuticals
Summary
References
Bibliography
Chapter 46 Pharmaceutical nanotechnology and nanomedicines
Chapter Contents
Key Points
Introduction
Applications of pharmaceutical nanotechnology
Polymer–drug conjugates
Antibodies and antibody–drug conjugates
Dendrimers
Micelle systems
Solid nanoparticles
Liposomes and bilayer vesicles
Lipid nanoparticles
Microcapsules and microspheres
Ongoing developments
Bibliography
Chapter 47 Radiopharmaceuticals
Chapter Contents
Key Points
Introduction
Design of radiopharmaceuticals
Delivery and localization of radiopharmaceuticals
Formulation of radiopharmaceuticals
Radionuclide production: cyclotrons, reactors and radionuclide generators
Functions of a radiopharmacy facility
Summary
Bibliography
Chapter 48 The formulation and manufacture of plant medicines
Chapter Contents
Key Points
Introduction
Plant-based products in medicinal use
Quality control of crude plant drugs
Production methods used to obtain plant-derived active constituents
Formulation and manufacture of plant-based medicines
Summary
References
Bibliography
Chapter 49 Design and administration of medicines for paediatric and geriatric patients
Chapter Contents
Key Points
Human development, ageing and drug administration
Formulation design for paediatric and geriatric patients
Adaptation of existing dosage forms
Future developments in the formulation of paediatric and geriatric medicines
Summary
References
Bibliography
Part 6 Packaging, stability and pharmaceutical regulation
Chapter 50 Packaging
Chapter Contents
Key Points
Introduction
The pharmaceutical pack
Packaging materials
Packaging and regulatory bodies
Repackaging
Designing packaging for safe medicine use
Medicine packaging and environmental sustainability
References
Bibliography
Chapter 51 Chemical stability in dosage forms
Chapter Contents
Key Points
Introduction
Chemical degradation reactions
Stability of proteins and peptides
Stability of antibody–drug conjugates
Bibliography
Chapter 52 Microbial contamination, spoilage and preservation of medicines
Chapter Contents
Key Points
The need to protect medicines against microbial spoilage
Products and materials vulnerable to spoilage
Sources and control of microbial contamination
Selection and use of antimicrobial preservatives
Preservative interactions with formulation components and containers
References
Bibliography
Chapter 53 Product stability and stability testing
Chapter Contents
Key Points
Introduction
Mechanisms of degradation
Stability testing of pharmaceutical products
Summary
References
Bibliography
Chapter 54 Pharmaceutical quality: the application of pharmaceutics in medicines regulation
Chapter Contents
Key Points
Quality, safety and efficacy
Pharmaceutical quality
Medicines regulation
Common Technical Document
Drug substance
Drug product
Regulatory applications for generic medicinal products (abridged applications)
Good Manufacturing Practice
UnlicenSed medicines and off-label use of licenSed medicines
Summary
References
Bibliography
Index